Crystal structure of the glutamate receptor GluA1 N-terminal domain

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	Crystal structure of the glutamate receptor GluA1 N-terminal domain
	Yao, Guorui ; Zong, Yinong ; Gu, Shenyan ; Zhou, Jie ; Xu, Huaxi ; Mathews, Irimpan I. ; Jin, Rongsheng ; Xu HX(许华曦)
刊名	http://dx.doi.org/10.1042/BJ20110801
	2011-09-01
关键词	LIGAND-BINDING CORE NMDA RECEPTORS TETRAMERIZATION DOMAIN AMPA RECEPTORS ION CHANNELS SUBUNIT GLUR2 PROTEIN ACTIVATION IFENPRODIL
英文摘要	Department of Energy, Office of Biological and Environmental Research; National Institutes of Health, National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health [R21AG033813, R01GM090023]; Alfred; The AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) subfamily of iGluRs (ionotropic glutamate receptors) is essential for fast excitatory neurotransmission in the central nervous system. The malfunction of AMPARs (AMPA receptors) has been implicated in many neurological diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. The active channels of AMPARs and other iGluR subfamilies are tetramers formed exclusively by assembly of subunits within the same subfamily. It has been proposed that the assembly process is controlled mainly by the extracellular ATD (N-terminal domain) of iGluR. In addition, ATD has also been implicated in synaptogenesis, iGluR trafficking and trans-synaptic signalling, through unknown mechanisms. We report in the present study a 2.5 angstrom (1 angstrom = 0.1 nm) resolution crystal structure of the ATD of GluA1. Comparative analyses of the structure of GluA1-AID and other subunits sheds light on our understanding of how ATD drives subfamily-specific assembly of AMPARs. In addition, analysis of the crystal lattice of CILIA] AID suggests a novel mechanism by which the ATD might participate in inter-tetramer AMPAR clustering, as well as in trans-synaptic protein protein interactions.
语种	英语
出版者	BIOCHEM J
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93233]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Yao, Guorui,Zong, Yinong,Gu, Shenyan,et al. Crystal structure of the glutamate receptor GluA1 N-terminal domain[J]. http://dx.doi.org/10.1042/BJ20110801,2011.
APA	Yao, Guorui.,Zong, Yinong.,Gu, Shenyan.,Zhou, Jie.,Xu, Huaxi.,...&许华曦.(2011).Crystal structure of the glutamate receptor GluA1 N-terminal domain.http://dx.doi.org/10.1042/BJ20110801.
MLA	Yao, Guorui,et al."Crystal structure of the glutamate receptor GluA1 N-terminal domain".http://dx.doi.org/10.1042/BJ20110801 (2011).