Reactive oxygen species: A double-edged sword in oncogenesis

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	Reactive oxygen species: A double-edged sword in oncogenesis
	Pan, Jin-Shui ; Hong, Mei-Zhu ; Ren, Jian-Lin ; Pan JS(潘金水) ; Ren JL(任建林)
刊名	http://dx.doi.org/10.3748/wjg.15.1702
	2009-04-14
关键词	KINASE-C-DELTA ACTIVATED PROTEIN-KINASE PROSTATE-CANCER CELLS NECROSIS-FACTOR-ALPHA OXIDATIVE STRESS SIGNALING PATHWAY INDUCED APOPTOSIS PC12 CELLS P38 MAPK HEPATOCELLULAR-CARCINOMA
英文摘要	National Natural Science Foundation of China [30750013]; Key Science Research Project Natural Science Foundation of Xiamen [WKZ0501]; Reactive oxygen species (ROS) are molecules or ions formed by the incomplete one-electron reduction of oxygen. Of interest, it seems that ROS manifest dual roles, cancer promoting or cancer suppressing, in tumorigenesis. ROS participate simultaneously in two signaling pathways that have inverse functions in tumorigenesis, Ras-Raf-MEK1/2-ERK1/2 signaling and the p38 mitogen-activated protein kinases (MAPK) pathway. It is well known that Ras-Raf-MEK1/2-ERK1/2 signaling is related to oncogenesis, while the p38 MAPK pathway contributes to cancer suppression, which involves oncogene-induced senescence, inflammation-induced cellular senescence, replicative senescence, contact inhibition and DNA-damage responses. Thus, ROS may not be an absolute carcinogenic factor or cancer suppressor. The purpose of the present review is to discuss the dual roles of ROS in the pathogenesis of cancer, and the signaling pathway mediating their role in tumorigenesis. (C) 2009 The WIG Press and Baishideng. All rights reserved.
语种	英语
出版者	WORLD J GASTROENTERO
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93148]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Pan, Jin-Shui,Hong, Mei-Zhu,Ren, Jian-Lin,et al. Reactive oxygen species: A double-edged sword in oncogenesis[J]. http://dx.doi.org/10.3748/wjg.15.1702,2009.
APA	Pan, Jin-Shui,Hong, Mei-Zhu,Ren, Jian-Lin,潘金水,&任建林.(2009).Reactive oxygen species: A double-edged sword in oncogenesis.http://dx.doi.org/10.3748/wjg.15.1702.
MLA	Pan, Jin-Shui,et al."Reactive oxygen species: A double-edged sword in oncogenesis".http://dx.doi.org/10.3748/wjg.15.1702 (2009).