Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics

CORC > 厦门大学 > 物理技术－已发表论文

	Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics
	Zhang, Linbao ; Liu, Xiaoli ; You, Liping ; Zhou, Di ; Wu, Huifeng ; Li, Lianzhen ; Zhao, Jianmin ; Feng, Jianghua ; Yu, Junbao ; Feng JH(冯江华)
刊名	http://dx.doi.org/10.1016/j.marenvres.2011.04.002
	2011-07
关键词	MAGNETIC-RESONANCE-SPECTROSCOPY MUSSEL MYTILUS-EDULIS PATTERN-RECOGNITION H-1-NMR METABOLOMICS TIDAL FLATS LIVER EXTRACTION POLLUTION DISEASE GALLOPROVINCIALIS
英文摘要	Chinese Academy of Sciences [KZCX2-YW-Q07-04]; Technology Development Program Projects of Shandong Province [2008GG20005006, 2008GG3NS0700]; SDSFC [ZR2009CZ008]; CAS/SAFEA; Copper is an important heavy metal contaminant with high ecological risk in the Bohai Sea. In this study, the metabolic responses in the bioindicator, Manila clam (Ruditapes philippinarum), to the environmentally relevant copper exposures were characterized using NMR-based metabolomics. The significant metabolic changes corresponding to copper exposures were related to osmolytes, intermediates of the Krebs cycle and amino acids, such as the increase in homarine, branched chain amino acids and decrease in succinate, alanine and dimethylamine in the copper-exposed clam gills during 96 h exposure period. Overall, Cu may lead to the disturbances in osmotic regulation and energy metabolism in clams during 96 h experimental period. These results demonstrate that NMR-based metabolomics is applicable for the discovery of metabolic biomarkers which could be used to elucidate the toxicological mechanisms of marine heavy metal contaminants. (C) 2011 Elsevier Ltd. All rights reserved.
语种	英语
出版者	MAR ENVIRON RES
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/91652]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics[J]. http://dx.doi.org/10.1016/j.marenvres.2011.04.002,2011.
APA	Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Wu, Huifeng.,...&冯江华.(2011).Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics.http://dx.doi.org/10.1016/j.marenvres.2011.04.002.
MLA	Zhang, Linbao,et al."Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics".http://dx.doi.org/10.1016/j.marenvres.2011.04.002 (2011).