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	视黄酸对胃癌细胞NM-IF系统变化的影响; Effect of Retinoic Acid on the Changes of NM IF System in Gastric Carcinoma Cells
	李祺福
	1998
关键词	视黄酸 胃癌细胞 核骨架－中间纤维系统 诱导分化 Retinoic acid Gastric Carcinoma cell NM IF system Induced differentiation
英文摘要	选择性抽提整装扫描与透射电镜观察显示，人胃腺癌MgC80-3细胞核骨架纤维和中间纤维数量较少、分布不均匀，核纤层为厚薄不一结构，与两类纤维联系不密切.经10-6MOl/lrA处理后，细胞核骨架纤维和中间纤维数量增多、结构层次丰富，分布均匀并相互交织成规则网络，两类纤维通过薄层均一的核纤层发生密切联系，形成贯穿整个细胞核质区域的完整体系.表明经rA诱导处理后MgC80-3细胞的核骨架-中间纤维系统产生了与正常细胞相似的恢复性改变.这种变化是癌细胞恶性表型逆转的重要形态特征和功能表现.; The configurational Changes of the nuclear matrix intermediate filament (NM IF)system in human gastric adenocarcinoma cell line MGc80 3 after being induced by retinoic acid(RA) have been investigated by selective extraction whole mountelectron microscopy.It was revaled by SEM and TEM that the NM and IF filaments in MGc80 3 cells was relatively few and scattered,not well distributed and arranged irregularly; The nuclear lamina was nonuniformly thick and compact,connected to NM and IF filaments relaxedly.But,in the cells induced by 10 -6 mol/L RA,the two kinds of filament were plentiful and well distributed, differed in slender and thick form and interweaved into a regular network.The NM and IF filaments connected closely by thin and compact fiber like lamina,and form a regular network through the whole cell region .It is demonstrated that the NM IF system in MGc80 3 cell had been undergone a restorational change similar to that of normal cells after RA treatment,and that this alternation is an important morphological and functional expression to the maligant phenotypic reversion of cancer cells.; 国家教委博士点基金
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/119495]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	李祺福. 视黄酸对胃癌细胞NM-IF系统变化的影响, Effect of Retinoic Acid on the Changes of NM IF System in Gastric Carcinoma Cells[J],1998.
APA	李祺福.(1998).视黄酸对胃癌细胞NM-IF系统变化的影响..
MLA	李祺福."视黄酸对胃癌细胞NM-IF系统变化的影响".(1998).

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