Genistein-Inhibited Cancer Stem Cell-Like Properties and Reduced Chemoresistance of Gastric Cancer

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	Genistein-Inhibited Cancer Stem Cell-Like Properties and Reduced Chemoresistance of Gastric Cancer
	Huang, Weifeng ; Wan, Chunpeng ; Luo, Qicong ; Huang, Zhengjie ; Luo, Qi ; Huang WF(黄卫锋) ; Huang ZJ(黄正接) ; Luo Q(罗琪)
刊名	http://dx.doi.org/10.3390/ijms15033432
	2014
关键词	BREAST-CANCER IDENTIFICATION ISOFLAVONE PHENOTYPE THERAPY CD44
英文摘要	Key Projects of Fujian Province Technology [2010D026]; China Postdoctoral Science Foundation [2012M521279]; Medical innovations Topic in Fujian Province [2012-CXB-9]; projects of Xiamen scientific and technological plan [3502Z20124018, 3502Z20134011]; Genistein, the predominant isoflavone found in soy products, has exerted its anticarcinogenic effect in many different tumor types in vitro and in vivo. Accumulating evidence in recent years has strongly indicated the existence of cancer stem cells in gastric cancer. Here, we showed that low doses of genistein (15 M), extracted from Millettia nitida Benth var hirsutissima Z Wei, inhibit tumor cell self-renewal in two types of gastric cancer cells by colony formation assay and tumor sphere formation assay. Treatment of gastric cancer cells with genistein reduced its chemoresistance to 5-Fu (fluorouracil) and ciplatin. Further results indicated that the reduced chemoresistance may be associated with the inhibition of ABCG2 expression and ERK 1/2 activity. Furthermore, genistein reduced tumor mass in the xenograft model. Together, genistein inhibited gastric cancer stem cell-like properties and reduced its chemoresistance. Our results provide a further rationale and experimental basis for using the genistein to improve treatment of patients with gastric cancer.
语种	英语
出版者	MDPI AG
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90822]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Huang, Weifeng,Wan, Chunpeng,Luo, Qicong,et al. Genistein-Inhibited Cancer Stem Cell-Like Properties and Reduced Chemoresistance of Gastric Cancer[J]. http://dx.doi.org/10.3390/ijms15033432,2014.
APA	Huang, Weifeng.,Wan, Chunpeng.,Luo, Qicong.,Huang, Zhengjie.,Luo, Qi.,...&罗琪.(2014).Genistein-Inhibited Cancer Stem Cell-Like Properties and Reduced Chemoresistance of Gastric Cancer.http://dx.doi.org/10.3390/ijms15033432.
MLA	Huang, Weifeng,et al."Genistein-Inhibited Cancer Stem Cell-Like Properties and Reduced Chemoresistance of Gastric Cancer".http://dx.doi.org/10.3390/ijms15033432 (2014).