Periostin Contributes to the Acquisition of Multipotent Stem Cell-Like Properties in Human Mammary Epithelial Cells and Breast Cancer Cells

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	Periostin Contributes to the Acquisition of Multipotent Stem Cell-Like Properties in Human Mammary Epithelial Cells and Breast Cancer Cells
	Wang, Xiaowei ; Liu, Jia ; Wang, Zhe ; Huang, Yangmei ; Liu, Weiping ; Zhu, Xiao ; Cai, Yao ; Fang, Xiaoguang ; Lin, Shuyong ; Yuan, Li ; Ouyang, Gaoliang ; Lin SY(林舒勇) ; Yuan L(袁立) ; 欧阳高亮
刊名	http://dx.doi.org/10.1371/journal.pone.0072962
	2013
关键词	MESENCHYMAL TRANSITION TUMOR-GROWTH PROTEIN EXPRESSION NICHE DIFFERENTIATION METASTASIS ACTIVATION INVASION REPAIR
英文摘要	National Nature Science Foundation of China [31171339, 31071302, 30871242]; National Basic Research Program of China [2009CB941601, 2010CB732402, 2011CBA01105]; Programme of Introducing Talents of Discipline to Universities [B12001]; Project of Education of China [B06016]; Fundamental Research Funds for the Central Universities [2010121095]; Program for New Century Excellent Talents in University; Scientific Fund for Distinguished Young Investigator of Fujian Province [2010J06013]; Periostin (POSTN), a recently characterised matricellular protein, is frequently dysregulated in various malignant cancers and promotes tumor metastatic growth. POSTN plays a critical role in the crosstalk between murine breast cancer stem cells (CSCs) and their niche to permit metastatic colonization. However, whether pro-metastatic capability of POSTN is associated with multipotent potentials of mesenchymal stem cells (MSCs) has not been documented. Here we demonstrate that POSTN promotes a stem cell-like trait and a mesenchymal phenotype in human mammary epithelial cells and breast cancer cells. Interestingly, ectopic overexpression of POSTN or recombinant POSTN treatment can induce human mammary epithelial cells and breast cancer cells differentiation into multiple cell lineages that recapitulate part of the multilineage differentiation potentials of MSCs. Moreover, POSTN is highly expressed in bone marrow-derived MSCs and their derived adipocytes, chondrocytes, and osteoblasts in vitro. Furthermore, POSTN promotes the growth of xenograft tumors in vivo. POSTN-overexpressing human mammary epithelial cells enhance breast tumor growth and metastasis. These data thus provide evidence of a new role for POSTN in mammary epithelial neoplasia and metastasis, suggesting that epithelial cancer cells might acquire CSC-like traits and a mesenchymal phenotype, as well as the multipotent potentials of MSCs to promote tumorigenesis and metastasis. Therefore, targeting POSTN and other extracellular matrix components of tumor microenvironment may help to develop new therapeutical strategies to inhibit tumor metastasis.
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90697]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Wang, Xiaowei,Liu, Jia,Wang, Zhe,et al. Periostin Contributes to the Acquisition of Multipotent Stem Cell-Like Properties in Human Mammary Epithelial Cells and Breast Cancer Cells[J]. http://dx.doi.org/10.1371/journal.pone.0072962,2013.
APA	Wang, Xiaowei.,Liu, Jia.,Wang, Zhe.,Huang, Yangmei.,Liu, Weiping.,...&欧阳高亮.(2013).Periostin Contributes to the Acquisition of Multipotent Stem Cell-Like Properties in Human Mammary Epithelial Cells and Breast Cancer Cells.http://dx.doi.org/10.1371/journal.pone.0072962.
MLA	Wang, Xiaowei,et al."Periostin Contributes to the Acquisition of Multipotent Stem Cell-Like Properties in Human Mammary Epithelial Cells and Breast Cancer Cells".http://dx.doi.org/10.1371/journal.pone.0072962 (2013).