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	Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced I kappa B phosphorylation and NF-kappa B activation
	Alpert, D. ; Schwenger, P. ; Han, J. H. ; Vilcek, J. ; Han JH(韩家淮)
	1999
关键词	IMMUNODEFICIENCY-VIRUS TYPE-1 SIGNAL-REGULATED KINASE JUN NH2-TERMINAL KINASE PROTEIN-KINASE SODIUM-SALICYLATE TRANSCRIPTION FACTOR INDUCED APOPTOSIS GENE-EXPRESSION TERMINAL KINASE ALPHA PHOSPHORYLATION
英文摘要	Tumor necrosis factor (TNF) exerts many actions through activation of the transcription factor NF-kappa B. NF-kappa B is sequestered in the cytosol by an inhibitory subunit I kappa B, which is inducibly phosphorylated by an I kappa B kinase complex and subsequently degraded. Sodium salicylate (NaSal) can block NF-kappa B activation by inhibiting I kappa B alpha phosphorylation. Recently, we used the specific p38 mitogen-activated protein (MAP) kinase inhibitor SB203580 to demonstrate that inhibition of TNF-induced I kappa B alpha phosphorylation requires NaSal-induced p38 activation. We demonstrate that NaSal similarly inhibits TNF-induced I kappa beta beta degradation in a p38-dependent manner. To further examine the role of p38, we determined whether other agents that activate p38 can block TNF-induced I kappa B phosphorylation and degradation. Sorbitol, H2O2, and arsenite each blocked I kappa B alpha phosphorylation induced by TNF, and SB203580 reversed the inhibitory effects of sorbitol and H2O2, but not arsenite. In addition, sorbitol and H2O2 blocked TNF-induced but not interleukin-1-induced I kappa B alpha phosphorylation, whereas arsenite inhibited I kappa B alpha phosphorylation induced by TNF and interleukin-1. Transient expression of MAP kinase kinase (MKK) 6b(E), a constitutive activator of p38, reduced both TNF-induced phosphorylation of I kappa B alpha and NF-kappa B-dependent reporter activity. However, MKK7(D), a constitutive activator of
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65844]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Alpert, D.,Schwenger, P.,Han, J. H.,et al. Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced I kappa B phosphorylation and NF-kappa B activation[J],1999.
APA	Alpert, D.,Schwenger, P.,Han, J. H.,Vilcek, J.,&韩家淮.(1999).Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced I kappa B phosphorylation and NF-kappa B activation..
MLA	Alpert, D.,et al."Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced I kappa B phosphorylation and NF-kappa B activation".(1999).

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