A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

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	A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells
	Wang, Guanghui ; Guo, Xiaoyu ; Chen, Haifeng ; Lin, Ting ; Xu, Yang ; Chen, Quancheng ; Liu, Jie ; Zeng, Jinzhang ; Zhang, Xiao-kun ; Yao, Xinsheng ; Ceng JZ(曾锦章)
刊名	http://dx.doi.org/10.1016/j.bmcl.2011.12.095
	2012-03-01
关键词	BCL-2 PROTEIN FAMILY LEUKEMIA CELLS RIBONUCLEOTIDE REDUCTASE GROWTH PROLIFERATION GRAPES
英文摘要	National Natural Science Foundation of China [NSFC-81001664]; Fundamental Research Funds for the Central Universities [2010121100]; Xiamen Science and Technology Key program [3502Z20100006]; Xiamen University; [2011121058]; Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R-OLFE, we found phoyunbene B (PYB, trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65140]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Wang, Guanghui,Guo, Xiaoyu,Chen, Haifeng,et al. A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells[J]. http://dx.doi.org/10.1016/j.bmcl.2011.12.095,2012.
APA	Wang, Guanghui.,Guo, Xiaoyu.,Chen, Haifeng.,Lin, Ting.,Xu, Yang.,...&曾锦章.(2012).A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.http://dx.doi.org/10.1016/j.bmcl.2011.12.095.
MLA	Wang, Guanghui,et al."A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells".http://dx.doi.org/10.1016/j.bmcl.2011.12.095 (2012).