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	Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway; 核孤儿受体TR3通过线粒体信号通路调控细胞自噬性死亡
	Wei-jia Wang ; Yuan Wang ; Hang-zi Chen ; Yong-zhen Xing ; Feng-wei Li ; Qian Zhang ; Bo Zhou ; Hong-kui Zhang ; Jie Zhang ; Xue-li Bian ; Li Li ; Yuan Liu ; Bi-xing Zhao ; Yan Chen ; rong Wu ; an-zhong Li ; Lu-ming Yao ; ping Chen ; Yi Zhang ; Xu-yang tian ; Friedrich Beermann ; Mian Wu ; Jiahuai Han ; pei-qiang Huang ; Huang PQ(黄培强) ; tianwei Lin ; Lin TW(林天伟) ; Qiao Wu ; Wu Q(吴乔)
	2013-12-08
英文摘要	Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear receptor TR3. A sequence of molecular events leading to cellular demise is launched by a specific chemical compound, 1-(3,4,5-trihydroxyphenyl)nonan-1-one, newly acquired from screening a library of TR3-targeting compounds. The autophagic cascade comprises TR3 translocation to mitochondria through interaction with the mitochondrial outer membrane protein Nix, crossing into the mitochondrial inner membrane through Tom40 and Tom70 channel proteins, dissipation of mitochondrial membrane potential by the permeability transition pore complex ANT1–VDAC1 and induction of autophagy. This process leads to excessive mitochondria clearance and irreversible cell death. It implicates a new approach to melanoma therapy through activation of a mitochondrial signaling pathway that integrates a nuclear receptor with autophagy for cell death.; http://news.xmu.edu.cn/s/13/t/542/2d/90/info142736.htm
语种	英语
出版者	Nature Publishing Group
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1038/nchembio.1406]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Wei-jia Wang,Yuan Wang,Hang-zi Chen,et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway, 核孤儿受体TR3通过线粒体信号通路调控细胞自噬性死亡[J],2013.
APA	Wei-jia Wang.,Yuan Wang.,Hang-zi Chen.,Yong-zhen Xing.,Feng-wei Li.,...&吴乔.(2013).Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway..
MLA	Wei-jia Wang,et al."Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway".(2013).

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