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	Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes
	Li, Hanjie ; Ye, Congting ; Ji, Guoli ; Wu, Xiaohui ; Xiang, Zhe ; Li, Yuanyue ; Cao, Yonghao ; Liu, Xiaolong ; Douek, Daniel C. ; Price, David A. ; Han, Jiahuai ; Han JH(韩家淮)
	2012-09-01
关键词	T-CELL REPERTOIRE V(D)J RECOMBINATION POSITIVE SELECTION RECEPTOR BIAS DIVERSITY RESPONSES IMMUNITY USAGE CDR3
英文摘要	Overlap of TCR repertoires among individuals provides the molecular basis for public T cell responses. By deep-sequencing the TCR beta repertoires of CD4(+)CD8(+) thymocytes from three individual mice, we observed that a substantial degree of TCR beta overlap, comprising similar to 10-15% of all unique amino acid sequences and similar to 5-10% of all unique nucleotide sequences across any two individuals, is already present at this early stage of T cell development. The majority of TCR beta sharing between individual thymocyte repertoires could be attributed to the process of convergent recombination, with additional contributions likely arising from recombinatorial biases; the role of selection during intrathymic development was negligible. These results indicate that the process of TCR gene recombination is the major determinant of clonotype sharing between individuals. The Journal of Immunology, 2012, 189: 2404-2413.; 973 Program [2009CB522200]; Natural Science Foundation of China [30830092, 30921005, 91029304, 81061160512, 61174161]; Specialized Research Fund for the Doctoral Program of Higher Education of China [20090121110022]; Fundamental Research Funds for the Central Universities of Xiamen University [2011121047, 201112G018, CXB2011035]
语种	英语
出版者	AMER ASSOC IMMUNOLOGISTS
内容类型	期刊论文
源URL	[http://dx.doi.org/10.4049/jimmunol.1102087]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Li, Hanjie,Ye, Congting,Ji, Guoli,et al. Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes[J],2012.
APA	Li, Hanjie.,Ye, Congting.,Ji, Guoli.,Wu, Xiaohui.,Xiang, Zhe.,...&韩家淮.(2012).Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes..
MLA	Li, Hanjie,et al."Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes".(2012).

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