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	Effects of virus infection on expression of cell cycle regulatory proteins in the unicellular marine algae Emiliania huxleyi
	Bratbak, ( Univ Bergen) ; Gunnar, ( Univ Bergen) ; Zheng, Tianling ; Zheng TL(郑天凌) ; Thyrhaug, (Univ Bergen) ; Runar, (Univ Bergen)
	2011-07
关键词	marine algal virus cell cycle regulators expression Emiliania huxleyi
英文摘要	The authors have investigated the biochemical events by which marine algal virus infection induces cell cycle arrest. The key G(2)/M-phase regulatory proteins are analyzed by immunobloting in unicellular Emiliania huxleyi, suggesting that virus induced cell cycle arrest is related with virus's effect on cyclins and cyclin dependent kinases. E. huxleyi virus (EhV) represses Cdc2/cyclinB complex activity by inhibiting the activity of Cdc2 kinase in a phosphorylation-related manner, blocking host cells G(2)/M checkpoint. Dephosphorylated / inactive Cdc25C combined with up-regulation of Wee1 expression at early infect period appears to be important mechanisms by which EhV represses Cdc2/cyclinB complex activity that is required for entry into M phase. This study has allowed us to confirm that algal virus infection leads to selective activation or inhibition of certain cell-cycle factors, which may play a significant role in establishing a more efficient environment for viral gene expression and DNA replication.; SPRINGER
语种	英语
内容类型	演示报告
源URL	[http://dx.doi.org/doi:10.1007/s13131-011-0138-z]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Bratbak, ,Gunnar, ,Zheng, Tianling,et al. Effects of virus infection on expression of cell cycle regulatory proteins in the unicellular marine algae Emiliania huxleyi. 2011.

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