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	FRS2 alpha is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts
	Wallace L. ; Zhang, Yongyou ; Liu, Leyuan ; McKeehan ; Wang, Fen ( Texas A&M Hlth Sci Ctr) ; Lin, Xiang ; Shen, Yuemao ; Shen YM(沈月毛) ; Song, Siyang ; Song SY(宋思扬)
	2011
关键词	FGF autophagy mouse embryonic fibroblast receptor tyrosine kinase cell signaling
英文摘要	Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2 alpha null mouse embryonic fibroblast (MEF) in conjunction with inhibitors to multiple signaling pathways, here we report that the FGF signaling axis activates mTOR via the FGF receptor substrate 2 alpha (FRS2 alpha)-mediated PI3K/Akt pathway, and suppresses autophagy activity in MEFs. In addition, the PI3K/Akt pathway regulated mTOR is crucial for the FGF signaling axis to suppress autophagy in MEFs. Since autophagy has been proposed to play important roles in cell survival, proliferation, and differentiation, the findings suggest a novel mechanism for the FGF signaling axis to transmit regulatory signals to downstream effectors.; NCI[CA96824, P50 CA140388]; Cancer Prevention & Research Institute of Texas[RP110555]
语种	英语
出版者	IVYSPRING INT PUBL
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.7150/ijbs.7.1114]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Wallace L.,Zhang, Yongyou,Liu, Leyuan,et al. FRS2 alpha is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts[J],2011.
APA	Wallace L..,Zhang, Yongyou.,Liu, Leyuan.,McKeehan.,Wang, Fen .,...&宋思扬.(2011).FRS2 alpha is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts..
MLA	Wallace L.,et al."FRS2 alpha is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts".(2011).

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