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	统计学建模在中药谱-效关系研究中的应用; Study on application of statistical modeling on chromatogram-effect relation in Traditional Chinese Medicine
	Li J(李嘉) ; Chen MY(陈曼译) ; Zhang Y(张颖) ; Yang HC(杨海船) ; He CH(何春欢) ; Jiang PC(姜平川)
	2013-12-25
关键词	钩藤 生物碱 谱-效关系方程 Uncaria Macrophylla Wall Alkaloid Mathematical Equation of Chromatogram-effect relationship
英文摘要	目的构建钩藤药材中钩藤碱、异钩藤碱、柯诺辛及柯诺辛b四种生物碱对谷氨酸酯诱导PC12细胞氧化应激抑制作用的谱-效关系模型。方法在获得钩藤药材中钩藤碱、异钩藤碱、柯诺辛及柯诺辛b四种生物碱对谷氨酸酯诱导的PC12氧化应激的抑制作用的谱-效关系基础上,利用SPSS 15.0软件进行分析,建立谱-效关系模型。结果钩藤碱和柯诺辛对PC12细胞氧化应激有显著的抑制作用,其谱-效方程为:y=44.301+0.255X1+0.356X3,经7批药材验证,谱-效关系式计算值与实际值的偏差率不超过10%。结论该谱-效关系模式可用于预测钩藤对谷氨酸酯诱导的PC12细胞氧化应激的抑制作用。; Objective To establish chromatogram-effect model based on inhibitory effect of four alkaloids( rhynchophyline,isorhynchophylline,corynoxine,corynoxine B) on oxidative stress of glutamate-induced PC12 cells.Methods Based on the chromatogram-effect relation of inhibitory effect of four alkaloids on the oxidative stress of glutamate-induced PC12 cells,SPSS 15.0 was used to analyse data.Results Oxidative stress of PC12 cells was significantly inhibited by rhynchophyline and corynoxine.The spectrum efficient equation was,Y = 44.301 + 0.255X 1 + 0.356X 3( P <0.05).The deviation of predictive value and true value was no more than 10% by data validation from seven samples.Conclusions The chromatogram-effect model can be used to predict the effect of uncaria macrophylla wall against the oxidative stress of glutamate-induced PC12 cells.
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/106880]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	李嘉,陈曼译,张颖,等. 统计学建模在中药谱-效关系研究中的应用, Study on application of statistical modeling on chromatogram-effect relation in Traditional Chinese Medicine[J],2013.
APA	李嘉,陈曼译,张颖,杨海船,何春欢,&姜平川.(2013).统计学建模在中药谱-效关系研究中的应用..
MLA	李嘉,et al."统计学建模在中药谱-效关系研究中的应用".(2013).

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