Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control

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	Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control
	Huang, Guoming ; Li, Hui ; Chen, Jiahe ; Zhao, Zhenghuan ; Yang, Lijiao ; Chi, Xiaoqin ; Chen, Zhong ; Wang, Xiaomin ; Gao, Jinhao ; Chi XQ(池小琴) ; Chen Z(陈忠) ; Wang XM(王效民) ; Gao JH(高锦豪)
刊名	http://dx.doi.org/10.1039/c4nr02680b
	2014
关键词	Magnetic resonance imaging Manganese Metal nanoparticles Molecular imaging
英文摘要	In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance the diagnostic accuracy of MRI, large numbers of contrast agents with T 1 or T2 contrast ability have been widely explored. The comprehensive investigation of high-performance MRI contrast agents with controllable T1 and T2 contrast abilities is of high importance in the field of molecular imaging. In this study, we synthesized uniform manganese-doped iron oxide (MnIO) nanoparticles with controllable size from 5 to 12 nm and comprehensively investigated their MRI contrast abilities. We revealed that the MRI contrast effects of MnIO nanoparticles are highly size-dependent. By controlling the size of MnIO nanoparticles, we can achieve T1-dominated, T2-dominated, and T1-T 2 dual-mode MRI contrast agents with much higher contrast enhancement than the corresponding conventional iron oxide nanoparticles. ? 2014 the Partner Organisations.
语种	英语
出版者	Royal Society of Chemistry
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89887]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Huang, Guoming,Li, Hui,Chen, Jiahe,et al. Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control[J]. http://dx.doi.org/10.1039/c4nr02680b,2014.
APA	Huang, Guoming.,Li, Hui.,Chen, Jiahe.,Zhao, Zhenghuan.,Yang, Lijiao.,...&高锦豪.(2014).Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control.http://dx.doi.org/10.1039/c4nr02680b.
MLA	Huang, Guoming,et al."Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control".http://dx.doi.org/10.1039/c4nr02680b (2014).