Target-Responsive "Sweet" Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets

CORC > 厦门大学 > 化学化工－已发表论文

	Target-Responsive "Sweet" Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets
	Yan, Ling ; Zhu, Zhi ; Zou, Yuan ; Huang, Yishun ; Liu, Dewen ; Jia, Shasha ; Xu, Dunming ; Wu, Min ; Zhou, Yu ; Zhou, Shuang ; Yang, Chaoyong James ; Zhu Z(朱志) ; Yang CY(杨朝勇)
刊名	http://dx.doi.org/10.1021/ja3114714
	2013
关键词	ECGONINE METHYL-ESTER MASS-SPECTROMETRY LIQUID-CHROMATOGRAPHY ASPERGILLUS-NIGER CARE DIAGNOSTICS VISUAL DETECTION BETA-AMYLASE HUMAN HAIR COCAINE METABOLITES
英文摘要	National Basic Research Program of China [2010CB732402]; National Natural Science Foundation of China [21205100, 21275122, 21075104]; Natural Science Foundation of Fujian Province for Distinguished Young Scholars [2010J06004]; National Instrumentation Program [2011YQ03012412]; National Fund for Fostering Talents of Basic Science [J1210014]; General Administration of Quality Supervision, Inspection and Quarantine [2010IK150, 2012JK052]; Portable devices with the advantages of rapid, on-site, user-friendly, and cost-effective assessment are widely applied in daily life. However, only a limited number of quantitative portable devices are commercially available, among which the personal glucose meter (PGM) is the most successful example and has been the most widely used. However, PGMs can detect only blood glucose as the unique target. Here we describe a novel design that combines a glucoamylase-trapped aptamer-cross-linked hydrogel with a PGM for portable and quantitative detection of non-glucose targets. Upon target introduction, the hydrogel collapses to release glucoamylase, which catalyzes the hydrolysis of amylose to produce a large amount of glucose for quantitative readout by the PGM. With the advantages of low cost, rapidity, portability, and ease of use, the method reported here has the potential to be used by the public for portable and quantitative detection of a wide range of non-glucose targets.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89096]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Yan, Ling,Zhu, Zhi,Zou, Yuan,et al. Target-Responsive "Sweet" Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets[J]. http://dx.doi.org/10.1021/ja3114714,2013.
APA	Yan, Ling.,Zhu, Zhi.,Zou, Yuan.,Huang, Yishun.,Liu, Dewen.,...&杨朝勇.(2013).Target-Responsive "Sweet" Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets.http://dx.doi.org/10.1021/ja3114714.
MLA	Yan, Ling,et al."Target-Responsive "Sweet" Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets".http://dx.doi.org/10.1021/ja3114714 (2013).