Engineered Iron-Oxide-Based Nanoparticles as Enhanced T-1 Contrast Agents for Efficient Tumor Imaging

CORC > 厦门大学 > 化学化工－已发表论文

	Engineered Iron-Oxide-Based Nanoparticles as Enhanced T-1 Contrast Agents for Efficient Tumor Imaging
	Zhou, Zijian ; Wang, Lirong ; Chi, Xiaoqin ; Bao, Jianfeng ; Yang, Lijiao ; Zhao, Wenxiu ; Chen, Zhong ; Wang, Xiaomin ; Chen, Xiaoyuan ; Gao, Jinhao ; Chi XQ(池小琴) ; Wang XM(王效民) ; Chen XY(陈小元) ; Gao JH(高锦豪)
刊名	http://dx.doi.org/10.1021/nn305991e
	2013
关键词	MULTIFUNCTIONAL MAGNETIC NANOPARTICLES NEPHROGENIC SYSTEMIC FIBROSIS BIOLOGICAL APPLICATIONS BIOMEDICAL APPLICATIONS QUANTUM DOTS RESONANCE MRI DESIGN SIZE BIODISTRIBUTION
英文摘要	National Key Basic Research Program of China [2013CB933901, 2013CB8733802]; National Natural Science Foundation of China [21021061, 21222106, 81000662, 81201805]; Program for New Century Excellent Talents in University [NCET-10-0709]; We report the design and synthesis of small-sized zwitterion-coated gadolinium-embedded iron oxide (Gd10) nanopartides, which exhibit a strong 71 contrast effect for tumor imaging through enhanced permeation and retention effect and the ability to clear out of the body in living subjects. The combination of spincanting effects and the collection of gadolinium species within small-sized Gd10 nanoparticles led to a significantly enhanced 71 contrast effect. For example, Gd10 nanoparticles with a diameter of similar to 4.8 nm exhibited a high r(1), relaxivity of 7.85 mM(-1) S-1 and a low r(2)/r(1) ratio of 5.24. After being coated with zwitterionic dopamine sulfonate molecules, the 4.8 nm Gd10 nanoparticles showed a steady hydrodynamic diameter (similar to 5.2 nm) in both PBS buffer and fetal bovine serum solution, indicating a low nonspecific protein absorption. This study provides a valuable strategy for the design of highly sensitive iron-oxide-based T-1 contrast agents with relatively long circulation half-lives (similar to 50 min), efficient tumor passive targeting (SKOV3, human ovarian cancer xenograft tumor as a model), and the possibility of rapid renal clearance after tumor imaging.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89077]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Zhou, Zijian,Wang, Lirong,Chi, Xiaoqin,et al. Engineered Iron-Oxide-Based Nanoparticles as Enhanced T-1 Contrast Agents for Efficient Tumor Imaging[J]. http://dx.doi.org/10.1021/nn305991e,2013.
APA	Zhou, Zijian.,Wang, Lirong.,Chi, Xiaoqin.,Bao, Jianfeng.,Yang, Lijiao.,...&高锦豪.(2013).Engineered Iron-Oxide-Based Nanoparticles as Enhanced T-1 Contrast Agents for Efficient Tumor Imaging.http://dx.doi.org/10.1021/nn305991e.
MLA	Zhou, Zijian,et al."Engineered Iron-Oxide-Based Nanoparticles as Enhanced T-1 Contrast Agents for Efficient Tumor Imaging".http://dx.doi.org/10.1021/nn305991e (2013).