Microcrystallization of lactose during droplet drying and its effect on the property of the dried particle

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	Microcrystallization of lactose during droplet drying and its effect on the property of the dried particle
	Fu, Nan ; Woo, Meng Wai ; Moo, Fei Tzhung ; Chen, Xiao Dong ; Chen XD(陈晓东)
刊名	http://dx.doi.org/10.1016/j.cherd.2011.06.016
	2012-01
关键词	ALPHA-LACTOSE CRYSTALLIZATION KINETICS AQUEOUS-SOLUTION SPRAY DRYER MONOHYDRATE NUCLEATION CRYSTALS SIZE AIR
英文摘要	Spray dried products with controlled crystallinity is desired to realize an improved quality and functionality of the final products. This study used the glass-filament single droplet drying technique to study lactose crystallization behaviour during convective drying. Single lactose droplets with different proportions of alpha- and beta-isomers were subjected to air drying temperatures of 70 degrees C and 110 degrees C. Lactose particles dried at 70 degrees C with higher initial proportions of alpha-isomer showed the lowest dissolution rate. XRD analysis on the freshly dried particles showed that higher crystallinity was achieved with a higher air drying temperature and a higher initial alpha-isomer proportion. This observation was confirmed with the SEM observation of lactose particles that were both freshly dried and with a post-drying crystallization process. Dried lactose particles could have a two-layer morphology where the surface shell and the interior part possess different crystallinity, due to the different crystallization kinetics during drying. The results suggest that during drying there is a critical crystallization stage where both droplet temperature and moisture content are sufficiently high, constituting large T - T-g driving force. For rapid crystallization to occur. The findings provide experimental support for the solid-phase crystallization theory. (C) 2011 Published by Elsevier B.V. on behalf of The Institution of Chemical Engineers.
语种	英语
出版者	CHEM ENG RES DES
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88381]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Fu, Nan,Woo, Meng Wai,Moo, Fei Tzhung,et al. Microcrystallization of lactose during droplet drying and its effect on the property of the dried particle[J]. http://dx.doi.org/10.1016/j.cherd.2011.06.016,2012.
APA	Fu, Nan,Woo, Meng Wai,Moo, Fei Tzhung,Chen, Xiao Dong,&陈晓东.(2012).Microcrystallization of lactose during droplet drying and its effect on the property of the dried particle.http://dx.doi.org/10.1016/j.cherd.2011.06.016.
MLA	Fu, Nan,et al."Microcrystallization of lactose during droplet drying and its effect on the property of the dried particle".http://dx.doi.org/10.1016/j.cherd.2011.06.016 (2012).