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	Asymmetric synthesis of (+)-L-733, 060 and (+)-CP-99, 994 based on a new chiral 3-piperidinol synthon
	Huang, PQ ; Huang PQ(黄培强) ; Liu, LX ; Wei, BG ; Ruan, YP ; Ruan YP(阮源萍)
	2003-05-07
英文摘要	[GRAPHIC] Selective and potent neurokinin substance P receptor antagonists (+)-L-733, 060 (1) and (+)-CP-99, 994 (2) have been synthesized starting from a new (3S)-piperidinol synthon derived from L-glutamic acid. The methods featured a C-2 regioselective reduction of glutarimide (9), Lewis acid-promoted Si to C-2 phenyl group migration of 10, and stereoselective reduction of acetylated oxime 19 as the key steps.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1021/ol034505g]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Huang, PQ,Huang PQ,Liu, LX,et al. Asymmetric synthesis of (+)-L-733, 060 and (+)-CP-99, 994 based on a new chiral 3-piperidinol synthon[J],2003.
APA	Huang, PQ,黄培强,Liu, LX,Wei, BG,Ruan, YP,&阮源萍.(2003).Asymmetric synthesis of (+)-L-733, 060 and (+)-CP-99, 994 based on a new chiral 3-piperidinol synthon..
MLA	Huang, PQ,et al."Asymmetric synthesis of (+)-L-733, 060 and (+)-CP-99, 994 based on a new chiral 3-piperidinol synthon".(2003).

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