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	Electric Field Assisted Surface Plasmon-Coupled Directional Emission: An Active Strategy on Enhancing Sensitivity for DNA Sensing and Efficient Discrimination of Single Base Mutation
	Cao, Shuo-Hui ; Xie, Tang-Tang ; Cai, Wei-Peng ; Liu, Qian ; Li, Yao-Qun ; Li YQ(李耀群)
	2011-01-25
英文摘要	We have demonstrated the proof-of-principle of electric field assisted surface plasmon-coupled directional emission (E-SPCDE). The combination of SPCDE and electric field control produced a significant synergistic effect to amplify the right signal and suppress the wrong signal intelligently in an active strategy. A novel hairpin structured DNA biosensor based on the quenching and enhancing of fluorescence in SPCDE has been designed. With modulation of the fluorescence coupling efficiency, a high discrimination ratio up to more than 20-fold has been achieved by enhancing the signal of match and suppressing that of mismatch. E-SPCDE has shown a successful application in DNA sensing, eliminating false positives and false negatives in the detection. E-SPCDE should provide an opportunity to create a new generation of miniaturized high-performance sensing platforms especially in chip-based microarrays and to make the manipulation of the nanometer-scale processes more accessible and detectable.; NSFC[20975084, 20575055]; 973 Program of China[2007CB935600]
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1021/ja107964s]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Cao, Shuo-Hui,Xie, Tang-Tang,Cai, Wei-Peng,et al. Electric Field Assisted Surface Plasmon-Coupled Directional Emission: An Active Strategy on Enhancing Sensitivity for DNA Sensing and Efficient Discrimination of Single Base Mutation[J],2011.
APA	Cao, Shuo-Hui,Xie, Tang-Tang,Cai, Wei-Peng,Liu, Qian,Li, Yao-Qun,&李耀群.(2011).Electric Field Assisted Surface Plasmon-Coupled Directional Emission: An Active Strategy on Enhancing Sensitivity for DNA Sensing and Efficient Discrimination of Single Base Mutation..
MLA	Cao, Shuo-Hui,et al."Electric Field Assisted Surface Plasmon-Coupled Directional Emission: An Active Strategy on Enhancing Sensitivity for DNA Sensing and Efficient Discrimination of Single Base Mutation".(2011).

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