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	Different alkyl dimethacrylate mediated stearyl methacrylate monoliths for improving separation efficiency of typical alkylbenzenes and proteins
	Xu, Zhendong ; Yang, Limin ; Wang, Qiuquan ; Wang QQ(王秋泉)
	2009-01
关键词	Monoliths Cross-linker Stearyl methacrylate Capillary liquid chromatography Protein Alkylbenzene
英文摘要	Monoliths were prepared in 530 mu m I.D. fused silica capillaries via in situ copolymerization of stearyl methacrylate (SMA) with a dimethacrylate cross-linker in the presence of a binary porogenic solvent containing tert.-butanol and 1,4-butanediol. Alkyl dimethacrylate cross-linkers other than the monomer were used to tune the monolith properties, and, as a result, an increase in the hydrophobicity of the final monoliths (the methylene selectivity alpha(CH2) increased from 1.396 to 1.475) was observed through an increase in the molecular chain length between two methacrylate units from the 0.360 nm of ethylene glycol dimethacrylate to the 1.241 nm of 1.9-nonanediol dimethacrylate. Moreover, the hydrophobicity of the final monoliths was also greatly affected by the methyl group branch in the cross-linkers, among which the 2-methyl-1,8-octanediol dimethacrylate(2-Me-1,8-ODDMA) mediated monolith exhibited the highest hydrophobicity (alpha(CH2), was 1.482) and fastest mass transfer kinetics (C-term was 9.14 ms). Besides the effective separation of six model proteins, the poly(SMA-co-2-Me-1,8-ODDMA) monolith also showed an improved performance in the separation of alkylbenzenes. The theoretical plate numbers reached 83 000 plates/m and 52 000 plates/m for thiourea (nonretained compound) and butylbenzene (retained compound), respectively, when using acetonitrile-water (70:30, v/v) as the mobile phase at a typical linear velocity of 1 mm/s. This improved performance towards small molecules was attributed to an increased mesopore proportion in the monolith and the faster dynamic process of mass transfer arising from novel tailoring of the monolith by choosing a suitable monomer/cross-linker pair. (C) 2009 Elsevier B.V. All rights reserved.; National Natural Science Foundation of China [20535020, 20775062]; National "863" Hi-Tech Project of China [2006AA06Z404]; National Basic Research Program of China [2009CBD421600]
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.chroma.2009.01.089]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Xu, Zhendong,Yang, Limin,Wang, Qiuquan,et al. Different alkyl dimethacrylate mediated stearyl methacrylate monoliths for improving separation efficiency of typical alkylbenzenes and proteins[J],2009.
APA	Xu, Zhendong,Yang, Limin,Wang, Qiuquan,&王秋泉.(2009).Different alkyl dimethacrylate mediated stearyl methacrylate monoliths for improving separation efficiency of typical alkylbenzenes and proteins..
MLA	Xu, Zhendong,et al."Different alkyl dimethacrylate mediated stearyl methacrylate monoliths for improving separation efficiency of typical alkylbenzenes and proteins".(2009).

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