Sensitive monitoring of penicillin antibiotics in milk and honey treated by stir bar sorptive extraction based on monolith and LC-electrospray MS detection

CORC > 厦门大学 > 海洋环境－已发表论文

	Sensitive monitoring of penicillin antibiotics in milk and honey treated by stir bar sorptive extraction based on monolith and LC-electrospray MS detection
	Huang, Xiaojia ; Chen, Linli ; Chen, Meng ; Yuan, Dongxing ; Nong, Shuyu ; Huang XJ(黄晓佳) ; Chen M(陈猛) ; Yuan DX(袁东星)
刊名	http://dx.doi.org/10.1002/jssc.201200987
	2013
关键词	BETA-LACTAM ANTIBIOTICS TANDEM MASS-SPECTROMETRY LIQUID-CHROMATOGRAPHY BOVINE-MILK RESIDUES MS/MS CONFIRMATION SAMPLES IONIZATION BIOSENSOR
英文摘要	National Natural Science Foundation of China [21077085]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry; Nature Science Foundation of Fujian Province of China [2010J01047]; Fundamental Research Funds for the Central Universities [CXB2011037]; In the present study, a convenient and sensitive method for determination of six penicillin antibiotics (amoxicillin, ampicillin, penicillin G, oxacillin, cloxacillin, and dicloxacillin) in milk and honey samples was developed. Milk and honey samples were diluted with water, then directly treated by stir bar sorptive extraction based on poly (vinylimidazole-divinylbenzene) monolithic material as coating. The analytes were analyzed by LC/ESI- MS/MS. Several extraction parameters including extraction and desorption time, pH value, and ionic strength in sample matrix were investigated in detail. Under the optimized extraction conditions, the calculated detection limits for the target compounds were as low as 0.23-2.66 ng/kg in milk and 0.18-1.42 ng/kg in honey, respectively. Good linearity was obtained for analytes with the correlation coefficients (R2) above 0.997. Excellent method reproducibility was achieved in terms of intraday and interday precisions, indicated by the RSDs of <5.0 and <10.0%, respectively. Finally, the proposed method was successfully applied to the determination of penicillin antibiotics residues in different milk and honey samples.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88066]
专题	海洋环境－已发表论文
推荐引用方式 GB/T 7714	Huang, Xiaojia,Chen, Linli,Chen, Meng,et al. Sensitive monitoring of penicillin antibiotics in milk and honey treated by stir bar sorptive extraction based on monolith and LC-electrospray MS detection[J]. http://dx.doi.org/10.1002/jssc.201200987,2013.
APA	Huang, Xiaojia.,Chen, Linli.,Chen, Meng.,Yuan, Dongxing.,Nong, Shuyu.,...&袁东星.(2013).Sensitive monitoring of penicillin antibiotics in milk and honey treated by stir bar sorptive extraction based on monolith and LC-electrospray MS detection.http://dx.doi.org/10.1002/jssc.201200987.
MLA	Huang, Xiaojia,et al."Sensitive monitoring of penicillin antibiotics in milk and honey treated by stir bar sorptive extraction based on monolith and LC-electrospray MS detection".http://dx.doi.org/10.1002/jssc.201200987 (2013).