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	Surgical Management of Patients With Insulinomas: Result of 292 Cases in a Single Institution
	Cao WQ(曹文清)
	2011
关键词	insulinoma surgical approach laparoscopy malignant complication
英文摘要	Background: Insulinoma is rare tumor with an incidence of approximately four cases per million per year. There are few large sample, single-center series that focus on the surgical management strategy of insulinomas. Patients and Methods: Medical records of patients diagnosed as insulinoma from 1990 to 2010 in Peking Union Medical College Hospital were reviewed retrospectively. Clinical data were collected and statistically analyzed. Results: A total of 328 patients were diagnosed with insulinomas; 292 of them underwent 320 operations, which included 46 laparoscopic surgeries. Tumor enucleation was the most common operative procedure. Multiple tumors were found in 30 cases; 17 cases were multiple endocrine neoplasial syndrome. Thirteen patients with malignant insulinomas underwent tumor resection. Pancreatic fistula (PF) was the most frequent complication, and the incidence of clinical PFs (Grades B and C) was 14.4%. There was no significant statistical difference between open and laparoscopic surgery in blood loss, operative time, and complications. Metachronous tumors were noted in 11 patients. Conclusion: Surgery is the best treatment of choice for insulinoma patients. Surgical approach depends on tumor size, location, and its pathological characters. Laparoscopic management of insulinomas is feasible and safe for tumors located in the body or tail of the pancreas. Open surgery combined with intraoperative ultrasonography is recommended to avoid omission of lesions in patients with multiple insulinomas. An aggressive surgical approach is indicated for malignant insulinoma patients. J. Surg. Oncol. 2011;103:169-174. (C) 2010 Wiley-Liss, Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/60278]
专题	海洋环境－已发表论文
推荐引用方式 GB/T 7714	Cao WQ. Surgical Management of Patients With Insulinomas: Result of 292 Cases in a Single Institution[J],2011.
APA	曹文清.(2011).Surgical Management of Patients With Insulinomas: Result of 292 Cases in a Single Institution..
MLA	曹文清."Surgical Management of Patients With Insulinomas: Result of 292 Cases in a Single Institution".(2011).

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