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	小动物PET/CT活体成像时小鼠体温控制系统的设计
	胡均松 ; 吴宁 ; 周丽娜 ; 高凯 ; 胡广书 ; 张辉 ; HU Junsong ; WU Ning ; ZHOU Lina ; GAO Kai ; HU Guangshu ; ZHANG Hui
	2016-03-30 ; 2016-03-30
关键词	正电子发射断层显像术 体层摄影术,X线计算机 体温 加热系统 疾病模型,动物 大鼠,裸 Positron-emission tomography Tomography,X-ray computed Body temperature Heating system Disease models,animal Rats,nude R730.44
其他题名	Design of Rat Body Temperature Control System in Micro PET/CT Vivo Imaging
中文摘要	目的设计出不影响图像质量的加热系统,以消除小动物PET/CT活体成像时影响肿瘤代谢的体温因素。材料与方法在研究易瑞沙疗效时发现,未使用加热系统时小鼠PET/CT图像的非特异性区域显著,但是肿瘤处不显著,严重影响了研究者对药物疗效的判断,需要设计加热系统使小动物在实验过程中体温保持恒定。实验中选择Siemens Inveon Micro PET/CT作为实验工具和环境,将镍铬电阻丝按照正弦形缠绕在盛放小鼠的碳纤维板上,利用Pt100温控电阻反馈碳纤维板的温度。加热前,碳纤维板的温度处于设定的下限(28℃)以下,继电器开关闭合,电源对电阻丝加热。当温度上升到设定的温度上限(30℃)时,继电器开关打开,电源停止加热。系统中电阻丝的发热功率为3.42 W,加热系统的产热量能够维持小鼠的体温稳定。结果加热后小鼠的PET/CT图像中,肿瘤处的成像得到明显改善,非特异性区域不再出现强放射性。在1%的显著水平下,与加热前相比,加热后5组小鼠肿瘤处的每克组织摄取率得到明显提升。结论安装加热系统后,系统不会产生影响小鼠图像的伪影,非特异性区域不再显著,肿瘤代谢正常。; Purpose To design a heating system without compromising image quality for removing the temperature factor which affects tumor metabolism in micro PET/CT vivo imaging. Materials and Methods In the study of Iressa, we found that when heating system was not used, non-specific areas were remarkable on rat PET/CT images but the tumor area was not specific, which seriously affected the determination of drug effect. Thus a heating system needed to be designed so that rat body temperature could remain stable during experiment. Siemens Inveon Micro PET/CT was selected as experimental tool and environment, nichrome resistance wire was wound sinusoidally on the carbon fiber sheet on which the rat laid, and Pt100 temperature sensor was used to control the sheet temperature. The sheet temperature was below the set minimum point(28 ℃) before heating. The relay switch was turned off and the resistance wire heated. When the temperature rose to the set maximum point(30 ℃), the switch was turned on to stop heating. The heating power of resistance wire in the system was 3.42 W, capable of maintaining stable body temperature of the rat. Results The tumor imaging was significantly improved on PET/CT after heating, and non-specific areas were no more with strong radioactivity. Compared with that before heating, the uptake rate of tumor tissue per gram of 5 groups of rats was significantly enhanced after heating with 1% significant level. Conclusion The heating system would not bring about artifact on rat imaging and could reduce marked non-specific areas without affecting tumor metabolism.
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://ir.lib.tsinghua.edu.cn/ir/item.do?handle=123456789/147441]
专题	清华大学
推荐引用方式 GB/T 7714	胡均松,吴宁,周丽娜,等. 小动物PET/CT活体成像时小鼠体温控制系统的设计[J],2016, 2016.
APA	胡均松.,吴宁.,周丽娜.,高凯.,胡广书.,...&ZHANG Hui.(2016).小动物PET/CT活体成像时小鼠体温控制系统的设计..
MLA	胡均松,et al."小动物PET/CT活体成像时小鼠体温控制系统的设计".(2016).

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