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	不同药物联合预防面神经显微血管减压术术后恶心呕吐的临床研究
	苗芳芳 ; 范婷 ; MIAO Fangfang ; FAN Ting
	2016-03-30 ; 2016-03-30
关键词	术后恶心呕吐 托烷司琼 地塞米松 氟哌利多 显微血管减压术 coronary heart disease homocystein young risk factors R614
其他题名	Effects of combined use of different antiemetics on postoperative nausea and vomiting after microvascular decompression
中文摘要	目的单一与联合预防性应用抗恶心呕吐药对行面神经显微血管减压术(MVD术)患者术后恶心呕吐(PONV)的影响。方法择期行MVD术患者57例,随机分为T+D+F组(诱导时给予托烷司琼5 mg+地塞米松4 mg,手术结束前10min给予氟哌利多0.625 mg),T+D组(诱导时给予托烷司琼5 mg+地塞米松4 mg),T组(诱导时给予托烷司琼5 mg),每组19例。记录拔管后0-2 h,3-6 h,7-24 h PONV及严重PONV发生率,以及不良反应发生情况。结果三组患者不良反应发生情况、各时间段PONV发生率、0-2 h和3-6 h发生PONV次数差异无统计学意义(P>0.05),拔管后7-24 h三组间两两比较,PONV发生次数均有差异(P<0.05),严重PONV的发生率T+D组和T+D+F组(P=0.012)、T组和T+D+F组(P<0.001)差异有统计学意义,而T+D组和T组差异无统计学意义(P=0.105)。结论对于行MVD术的高危PONV人群,托烷司琼、地塞米松、氟哌利多三药联合优于托烷司琼、地塞米松两药联合,托烷司琼、地塞米松两药联合优于单用托烷司琼。; Objective To explore the effects of combination of different antiemetics on postoperative nausea and vomiting( PONV) after microvascular decompression. Methods Fifty-seven ASA Ⅰ- Ⅱ patients scheduled for microvascular decompression were randomly allocated into three groups: T + D + F group( tropisetron 5 mg + dexamethasone 4 mg were given during the induction,droperidol0. 625 mg was given 10 min before the end of the surgery),T + D group( tropisetron 5 mg + dexamethasone 4 mg were given during the induction),T group( tropisetron 5 mg was given during the induction). Incidences of PONV,severe PONV and side effects were recorded during 0- 2 h,3- 6 h,and 7- 24 h after extubation,respectively. Results Incidences of side effects and PONV,and the times of nausea and vomiting during 0- 2 h and 3- 6 h were not statistically different among three groups( P > 0. 05). The times of nausea and vomiting during 7- 24 h were significantly lower in T + D + F group than in T + D group and T group,and also lower in T + D group than in T group. Incidence of severe PONV was lower in T + D + F group than in T + D group and T group. Conclusion Tropisetron+ dexamethasone + droperidol is better than tropisetron + dexamethasone for high risk PONV patients after MVD,and tropisetron + dexamethasone is better than tropisetron only on the prevention of PONV.
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://ir.lib.tsinghua.edu.cn/ir/item.do?handle=123456789/147225]
专题	清华大学
推荐引用方式 GB/T 7714	苗芳芳,范婷,MIAO Fangfang,等. 不同药物联合预防面神经显微血管减压术术后恶心呕吐的临床研究[J],2016, 2016.
APA	苗芳芳,范婷,MIAO Fangfang,&FAN Ting.(2016).不同药物联合预防面神经显微血管减压术术后恶心呕吐的临床研究..
MLA	苗芳芳,et al."不同药物联合预防面神经显微血管减压术术后恶心呕吐的临床研究".(2016).

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