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	Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway
	Zhang, Jin-fang ; Li, Guo ; Chan, Chu-yan ; Meng, Chun-ling ; Lin, Marie Chia-mi ; Chen, Yang-chao ; He, Ming-liang ; Leung, Ping-chung ; Kung, Hsiang-fu
	2010-10-12 ; 2010-10-12
关键词	BMP signaling pathway Wnt/beta-catenin signaling pathway Flavonoids of Herb Epidemium Mesenchymal stem cells Osteogenic differentiation OSTEOBLAST DIFFERENTIATION IN-VITRO RUNX2 EXPRESSION KOREANUM NAKAI BONE-FORMATION THERAPY GENE PROLIFERATION OSTEOPOROSIS SUPPRESSION Cell Biology Endocrinology & Metabolism
中文摘要	Herba Epimedii is one of the most commonly used Chinese herbs for treating osteoporosis. In the present study, the flavonoids of Herba Epimedii (HEF) have shown to promote the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. They were noted to enhance the mRNA expression of BMP-2, BMP-4, Runx2, beta-catenin and cyclinD1, all of which are BMP or Wnt-signaling pathway related regulators. The osteogenic effect was inhibited by the introduction of noggin and DKK-1, which is classical inhibitor of BMP and Wnt/beta-catenin signaling, respectively. These results suggest that HEF exerts promoting effect on osteogenic differentiation, which plausibly functions via the BMP and Wnt/beta-catenin signaling pathways. Considering the therapeutic efficiency and economical issues, HEF may be a potential candidate for promoting bone regeneration. On the other hand, osteogenic differentiation of MSCs may also be a promising and attractive tool to apply in bone repair. (C) 2009 Published by Elsevier Ireland Ltd.
语种	英语 ; 英语
出版者	ELSEVIER IRELAND LTD ; CLARE ; ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81904]
专题	清华大学
推荐引用方式 GB/T 7714	Zhang, Jin-fang,Li, Guo,Chan, Chu-yan,et al. Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway[J],2010, 2010.
APA	Zhang, Jin-fang.,Li, Guo.,Chan, Chu-yan.,Meng, Chun-ling.,Lin, Marie Chia-mi.,...&Kung, Hsiang-fu.(2010).Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway..
MLA	Zhang, Jin-fang,et al."Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway".(2010).

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