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	Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-beta Signaling
	Yan, Xiaohua ; Lin, Zhenghong ; Chen, Feng ; Zhao, Xingang ; Chen, Hua ; Ning, Yuanheng ; Chen, Ye-Guang
	2010-10-12 ; 2010-10-12
关键词	TGF-BETA TRANSCRIPTIONAL REGULATION PSEUDORECEPTOR BAMBI NEGATIVE REGULATION CELL-LINES RECEPTOR TRANSDUCTION EXPRESSION MEMBRANE GENE Biochemistry & Molecular Biology
中文摘要	Transforming growth factor beta (TGF-beta) and related growth factors are essential regulators of embryogenesis and tissue homeostasis. The signaling pathways mediated by their receptors and Smad proteins are precisely modulated by various means. Xenopus BAMBI (bone morphogenic protein (BMP) and activin membrane-bound inhibitor) has been shown to function as a general negative regulator of TGF-beta/BMP/activin signaling. Here, we provide evidence that human BAMBI (hBAMBI), like its Xenopus homolog, inhibits TGF-beta- and BMP-mediated transcriptional responses as well as TGF-beta-induced R-Smad phosphorylation and cell growth arrest, whereas knockdown of endogenous BAMBI enhances the TGF-beta-induced reporter expression. Mechanistically, in addition to interfering with the complex formation between the type I and type II receptors, hBAMBI cooperates with Smad7 to inhibit TGF-beta signaling. hBAMBI forms a ternary complex with Smad7 and the TGF-beta type I receptor ALK5/T beta RI and inhibits the interaction between ALK5/T beta RI and Smad3, thus impairing Smad3 activation. These findings provide a novel insight to understand the molecular mechanism underlying the inhibitory effect of BAMBI on TGF-beta signaling.
语种	英语 ; 英语
出版者	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC ; BETHESDA ; 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81880]
专题	清华大学
推荐引用方式 GB/T 7714	Yan, Xiaohua,Lin, Zhenghong,Chen, Feng,et al. Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-beta Signaling[J],2010, 2010.
APA	Yan, Xiaohua.,Lin, Zhenghong.,Chen, Feng.,Zhao, Xingang.,Chen, Hua.,...&Chen, Ye-Guang.(2010).Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-beta Signaling..
MLA	Yan, Xiaohua,et al."Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-beta Signaling".(2010).

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