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	A Novel Strategy for the Invasive Toxin: Hijacking Exosome-Mediated Intercellular Trafficking
	Zhang, Fan ; Sun, Shan ; Feng, Du ; Zhao, Wen-Long ; Sui, Sen-Fang
	2010-10-12 ; 2010-10-12
关键词	cell penetration exosome multivesicular body plant toxin ribosome-inactivating protein CELL-DERIVED EXOSOMES MULTIVESICULAR BODY FORMATION ANTHRAX PROTECTIVE ANTIGEN RICIN-A-CHAIN TRICHOSANTHES-KIRILOWII CHORIOCARCINOMA CELLS INWARD VESICULATION MEMBRANE INSERTION ENDOCYTIC PATHWAY K562 CELLS Cell Biology
中文摘要	Toxins penetrate mammalian cells through various means. In this study, we report a unique strategy used by trichosanthin (TCS), a plant toxin with ribosome-inactivating activity, to penetrate host cells. We found that in both JAR and K562 cells, endocytosed TCS is incorporated into intraluminal vesicles of the multivesicular body (MVB) and is then secreted in association with these vesicles upon fusion of the MVB with the plasma membrane. The secreted TCS-loaded vesicles secreted by K562 cells move throughout the intercellular space and target syngeneic and specific allogeneic cells. Subsequent internalization permits delivery of the toxin into the cytosol, resulting in ribosomal inactivation and cell death. Thus, our findings provide a novel mechanism by which foreign proteins pass between and penetrate into mammalian cells.
语种	英语 ; 英语
出版者	WILEY-BLACKWELL PUBLISHING, INC ; MALDEN ; COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81875]
专题	清华大学
推荐引用方式 GB/T 7714	Zhang, Fan,Sun, Shan,Feng, Du,et al. A Novel Strategy for the Invasive Toxin: Hijacking Exosome-Mediated Intercellular Trafficking[J],2010, 2010.
APA	Zhang, Fan,Sun, Shan,Feng, Du,Zhao, Wen-Long,&Sui, Sen-Fang.(2010).A Novel Strategy for the Invasive Toxin: Hijacking Exosome-Mediated Intercellular Trafficking..
MLA	Zhang, Fan,et al."A Novel Strategy for the Invasive Toxin: Hijacking Exosome-Mediated Intercellular Trafficking".(2010).

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