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	Effect of amyloid beta on capacitive calcium entry in neural 2a cells
	Niu, Ying ; Su, Zuqi ; Zhao, Chang ; Song, Bo ; Zhang, Xiufang ; Zhao, Nanming ; Shen, Xun ; Gong, Yandao
	2010-10-12 ; 2010-10-12
关键词	Alzheimer's disease Amyloid beta Capacitive calcium entry (CCE) ALZHEIMERS-DISEASE ION CHANNELS ZN2+-SENSITIVE CHANNEL MUTANT PRESENILIN-1 PRECURSOR PROTEIN CA2+ MUTATION Neurosciences
中文摘要	We studied the direct role of amyloid beta (A beta) in regulating capacitive calcium entry (CCE), an important refilling mechanism for depleted intracellular calcium stores. For the first time, we found that A beta can potentiate CCE. Neural 2a cells stably expressing Swedish mutant APP (APPswe), which can secrete large amounts of A beta, have stronger CCE than its wild-type controls. Either reducing the A beta in the medium by antibody binding or decreasing A beta production by gamma secretase inhibitor treatment could significantly depress CCE in APPswe cells. The results demonstrated that the CCE potentiation in APPswe cells was caused by A beta over-expression. Our research also revealed that the effect of A beta on CCE potentiation could be decreased by A beta channel blocker, which showed that the channels formed by A beta are one of the ways through which A beta causes CCE potentiation. (C) 2008 Elsevier Inc. All rights reserved.
语种	英语 ; 英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81802]
专题	清华大学
推荐引用方式 GB/T 7714	Niu, Ying,Su, Zuqi,Zhao, Chang,et al. Effect of amyloid beta on capacitive calcium entry in neural 2a cells[J],2010, 2010.
APA	Niu, Ying.,Su, Zuqi.,Zhao, Chang.,Song, Bo.,Zhang, Xiufang.,...&Gong, Yandao.(2010).Effect of amyloid beta on capacitive calcium entry in neural 2a cells..
MLA	Niu, Ying,et al."Effect of amyloid beta on capacitive calcium entry in neural 2a cells".(2010).

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