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	Growth of Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells on the Terpolyester Poly(3-hydroxybutyrate-co-3-hydroxyvalerateco-3-hydroxyhexanoate)
	Ji, Guang-Zhen ; Wei, Xing ; Chen, Guo-Qiang
	2010-10-12 ; 2010-10-12
关键词	Polyhydroxyalkanoates PHBV PHBHHx PLA mesenchymal stem cells POLY-BETA-HYDROXYBUTYRATE IN-VITRO OSTEOBLAST ADHESION SURFACE-ROUGHNESS PROLIFERATION POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYHEXANOATE) POLYHYDROXYALKANOATES BIOMATERIALS FIBROBLAST PROTEIN Engineering, Biomedical Materials Science, Biomaterials Polymer Science
中文摘要	As a new member of the polyhydroxyalkanoate (PHA) family, the terpolyester poly(3-hydroxybutyrateco-3- hydroxyvalerate-co-3-hydroxyhexanoate) (PHBVHHx) was evaluated for its biocompatibility for human umbilical cord Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs). More WJ-MSC adhesion and proliferation were observed on PHBVHHx film compared with films made of poly(L-lactic acid) (PLA), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx). Higher DNA synthesis by WJ-MSCs was detected on PHBVHHx film than on PLA, PHBV and PHBHHx films. PHBVHHx film had a rougher surface and more adsorption of extracellular matrix (ECM) proteins including collagen I, fibronectin and vitronectin, compared with PLA, PHBV and PHBHHx films. PHBVHHx film was also more hydrophobic than PLA and PHBV. These results demonstrated that PHBVHHx could be a promising biomaterial in medical implant applications for supporting the growth of cells, including WJ-MSCs. (c) Koninklijke Brill NV, Leiden, 2009
语种	英语 ; 英语
出版者	VSP BV ; LEIDEN ; BRILL ACADEMIC PUBLISHERS, PO BOX 9000, 2300 PA LEIDEN, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81766]
专题	清华大学
推荐引用方式 GB/T 7714	Ji, Guang-Zhen,Wei, Xing,Chen, Guo-Qiang. Growth of Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells on the Terpolyester Poly(3-hydroxybutyrate-co-3-hydroxyvalerateco-3-hydroxyhexanoate)[J],2010, 2010.
APA	Ji, Guang-Zhen,Wei, Xing,&Chen, Guo-Qiang.(2010).Growth of Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells on the Terpolyester Poly(3-hydroxybutyrate-co-3-hydroxyvalerateco-3-hydroxyhexanoate)..
MLA	Ji, Guang-Zhen,et al."Growth of Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells on the Terpolyester Poly(3-hydroxybutyrate-co-3-hydroxyvalerateco-3-hydroxyhexanoate)".(2010).

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