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	COMBINING GENERALIZED NMF AND DISCRIMINATIVE MIXTURE MODELS FOR CLASSIFICATION OF GENE EXPRESSION DATA
	Liu, Weixiang ; Yuan, Kehong ; Wu, Jian ; Ye, Datian ; Ji, Zhen ; Chen, Siping
	2010-10-12 ; 2010-10-12
关键词	Non-negative matrix factorization mixture model sparseness gene expression data classification dimension reduction NONNEGATIVE MATRIX FACTORIZATION COMPONENT ANALYSIS CLASS DISCOVERY CANCER PREDICTION PARTS Computer Science, Artificial Intelligence
中文摘要	Classification of gene expression samples is a core task in microarray data analysis. How to reduce thousands of genes and to select a suitable classifier are two key issues for gene expression data classification. This paper introduces a framework on combining both feature extraction and classifier simultaneously. Considering the non-negativity, high dimensionality and small sample size, we apply a discriminative mixture model which is designed for non-negative gene express data classification via non-negative matrix factorization (NMF) for dimension reduction. In order to enhance the sparseness of training data for fast learning of the mixture model, a generalized NMF is also adopted. Experimental results on several real gene expression datasets show that the classification accuracy, stability and decision quality can be significantly improved by using the generalized method, and the proposed method can give better performance than some previous reported results on the same datasets.
语种	英语 ; 英语
出版者	WORLD SCIENTIFIC PUBL CO PTE LTD ; SINGAPORE ; 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81754]
专题	清华大学
推荐引用方式 GB/T 7714	Liu, Weixiang,Yuan, Kehong,Wu, Jian,et al. COMBINING GENERALIZED NMF AND DISCRIMINATIVE MIXTURE MODELS FOR CLASSIFICATION OF GENE EXPRESSION DATA[J],2010, 2010.
APA	Liu, Weixiang,Yuan, Kehong,Wu, Jian,Ye, Datian,Ji, Zhen,&Chen, Siping.(2010).COMBINING GENERALIZED NMF AND DISCRIMINATIVE MIXTURE MODELS FOR CLASSIFICATION OF GENE EXPRESSION DATA..
MLA	Liu, Weixiang,et al."COMBINING GENERALIZED NMF AND DISCRIMINATIVE MIXTURE MODELS FOR CLASSIFICATION OF GENE EXPRESSION DATA".(2010).

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