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	Metabolomic profiling of rat serum associated with isoproterenol-induced myocardial infarction using ultra-performance liquid chromatography/time-of-flight mass spectrometry and multivariate analysis
	Zhang, Hong-yang ; Chen, Xi ; Hu, Ping ; Liang, Qiong-lin ; Liang, Xiao-ping ; Wang, Yi-ming ; Luo, Guo-an
	2010-10-12 ; 2010-10-12
关键词	Metabolomics Ultra-performance liquid chromatography/time-of-flight mass spectrometry (UPLC/TOF-MS) Multivariate analysis Myocardial infarction Lipid biomarkers LIPID-PEROXIDATION ARACHIDONIC-ACID HEART-DISEASE METABONOMICS REPERFUSION ISCHEMIA URINE MS Chemistry, Analytical
中文摘要	An ultra-performance liquid chromatography/time-of-flight mass spectrometry (UPLC/TOF-MS)-based metabolomic approach was developed to characterize the metabolic profile associated with isoproterenol (ISO)-induced myocardial infarction (MI). Analysis of the serum samples revealed distinct changes in the biochemical patterns of ISO-induced rats. A multivariate statistical method, supervised partial least squares-discriminant analysis (PLS-DA), was then used for screening of potential biomarkers. As a result, 13 lipid biomarkers, including lysophosphatidylcholines (Lyso-PCs) and fatty acids were identified by the accurate mass measurement of TOF-MS. The relationship between abnormal lipid metabolism and the formation of MI were also studied. This work demonstrates the utility of UPLC/TOF-MS-based metabolic profiling combined with multivariate analysis as a powerful tool to further investigate the pathogenesis of cardiovascular diseases. (C) 2009 Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81109]
专题	清华大学
推荐引用方式 GB/T 7714	Zhang, Hong-yang,Chen, Xi,Hu, Ping,et al. Metabolomic profiling of rat serum associated with isoproterenol-induced myocardial infarction using ultra-performance liquid chromatography/time-of-flight mass spectrometry and multivariate analysis[J],2010, 2010.
APA	Zhang, Hong-yang.,Chen, Xi.,Hu, Ping.,Liang, Qiong-lin.,Liang, Xiao-ping.,...&Luo, Guo-an.(2010).Metabolomic profiling of rat serum associated with isoproterenol-induced myocardial infarction using ultra-performance liquid chromatography/time-of-flight mass spectrometry and multivariate analysis..
MLA	Zhang, Hong-yang,et al."Metabolomic profiling of rat serum associated with isoproterenol-induced myocardial infarction using ultra-performance liquid chromatography/time-of-flight mass spectrometry and multivariate analysis".(2010).

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