| An Efficient Method for the Preparation of Versatile Building Blocks: 1-Substituted 2,2-Dimethoxyethylamine Hydrochlorides | |
| Liu, Bo ; Su, Deyong ; Cheng, Guolin ; Liu, Hui ; Wang, Xinyan ; Hu, Yuefei | |
| 2010-10-12 ; 2010-10-12 | |
| 关键词 | heterocycles alkylation N-debenzylation Betti base 2,2-dimethoxyethylamines NONRACEMIC BETTI BASE ALPHA-AMINO ALDEHYDES ARYL ALDEHYDES ENANTIOSELECTIVE ADDITION TERTIARY AMINONAPHTHOL KINETIC RESOLUTION CHIRAL LIGANDS DIETHYLZINC INHIBITORS LENNOXAMINE Chemistry, Organic |
| 中文摘要 | A novel method for the preparation of 1-substituted 2,2-dimethoxyethylamine hydrochlorides was developed. The method includes three highly efficient steps: (1) direct use of aqueous (MeO)(2)CHCHO for the preparation of N,O-acetal by condensation with Betti base without acidic catalyst; (2) regioselective alkylations of the NO-acetal with Grignard reagents; and (3) Pd/C catalytic hydrogenolyses of benzylamines in the presence of ClCH2CHCl2 to directly give the target products as crystalline amine hydrochlorides. The method reported is extremely convenient and highly efficient with wide substrate scopes. |
| 语种 | 英语 ; 英语 |
| 出版者 | GEORG THIEME VERLAG KG ; STUTTGART ; RUDIGERSTR 14, D-70469 STUTTGART, GERMANY |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/80813]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Liu, Bo,Su, Deyong,Cheng, Guolin,et al. An Efficient Method for the Preparation of Versatile Building Blocks: 1-Substituted 2,2-Dimethoxyethylamine Hydrochlorides[J],2010, 2010. |
| APA | Liu, Bo,Su, Deyong,Cheng, Guolin,Liu, Hui,Wang, Xinyan,&Hu, Yuefei.(2010).An Efficient Method for the Preparation of Versatile Building Blocks: 1-Substituted 2,2-Dimethoxyethylamine Hydrochlorides.. |
| MLA | Liu, Bo,et al."An Efficient Method for the Preparation of Versatile Building Blocks: 1-Substituted 2,2-Dimethoxyethylamine Hydrochlorides".(2010). |
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