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	The regulatory mechanism of Hsp90 alpha secretion and its function in tumor malignancy
	Wang, Xiaofeng ; Song, Xiaomin ; Zhuo, Wei ; Fu, Yan ; Shi, Hubing ; Liang, Yun ; Tong, Maomeng ; Chang, Guodong ; Luo, Yongzhang
	2010-10-12 ; 2010-10-12
关键词	heat shock protein 90-alpha extracellular nonconventional protein secretion MMP-2 tumor marker HSP90 MOLECULAR CHAPERONE HEAT-SHOCK PROTEINS SIGNAL-TRANSDUCTION MATRIX METALLOPROTEINASES GENE-EXPRESSION CELL MOTILITY KINASE-A METASTASIS CANCER GROWTH Multidisciplinary Sciences
中文摘要	Heat shock protein 90-alpha (Hsp90 alpha) is an intracellular molecular chaperone. However, it can also be secreted with the underlying regulatory mechanism remaining far from clear. Here we show that the secreted Hsp90 alpha is a C-terminal truncated form and its secretion is regulated by the C-terminal EEVD motif via interacting with proteins containing tetratricopeptide repeat domains. We also demonstrate that secretion of Hsp90 alpha is determined by the phosphorylation status at residue Thr-90, regulated by protein kinase A and protein phosphatase 5. We further demonstrate that the secretion of Hsp90 alpha is a prerequisite for its proinvasiveness function and blocking the secreted Hsp90 alpha results in significant inhibition of tumor metastasis. Meanwhile, the level of plasma Hsp90 alpha is positively correlated with tumor malignancy in clinical cancer patients. In sum, our results reveal the regulatory mechanism of Hsp90 alpha secretion, and its function in tumor invasiveness, indicating it can be a promising diagnostic marker for tumor malignancy in clinical application.
语种	英语 ; 英语
出版者	NATL ACAD SCIENCES ; WASHINGTON ; 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/78708]
专题	清华大学
推荐引用方式 GB/T 7714	Wang, Xiaofeng,Song, Xiaomin,Zhuo, Wei,et al. The regulatory mechanism of Hsp90 alpha secretion and its function in tumor malignancy[J],2010, 2010.
APA	Wang, Xiaofeng.,Song, Xiaomin.,Zhuo, Wei.,Fu, Yan.,Shi, Hubing.,...&Luo, Yongzhang.(2010).The regulatory mechanism of Hsp90 alpha secretion and its function in tumor malignancy..
MLA	Wang, Xiaofeng,et al."The regulatory mechanism of Hsp90 alpha secretion and its function in tumor malignancy".(2010).

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