| 热碘油联合~(90)Y瘤内注射治疗肝癌的实验研究 | |
| 牟培源 ; 陈靖 ; 孙锁柱 ; 王建晨 ; 蒋小良 ; 何千舸 ; 金美娟 ; MU Pei-yuan ; CHEN Jing ; SUN Suo-zhu | |
| 2010-06-04 ; 2010-06-04 | |
| 关键词 | 肝肿瘤 碘油 90钇 瘤内注射 liver neoplasms lipiodol ~(90)Y intratumor injection R735.7 |
| 其他题名 | Experimental study of hot lipiodol with ~(90)Y intratumor injection for treatment of liver cancer |
| 中文摘要 | 目的探讨热碘油联合90钇(90Y)瘤内注射治疗肝癌的安全性和可行性。方法将40只荷瘤昆明小鼠随机分为A、B、C、D组各10只。A组瘤内注射0.1m l热碘油与0.1m l(100μC i)90Y混悬液;B组注射0.1m l热碘油;C组注射0.1m l(100μC i)90Y;D组注射0.1m l生理盐水。A、C组注药后2h、3d、7d、10d、14d在γ相机和ECT扫描仪下观察放射性分布情况。各组在上述时间点抽血查肝、肾功能及血常规,并测肿瘤最大径a和最小径b,计算肿瘤体积及肿瘤生长率,同时取肿瘤组织作病理检查。结果除肿瘤外,A、C组小鼠其他脏器内均未发现90Y沉积,病理切片也未显示小鼠其他脏器因90Y放射损伤所致的病理改变。A、B、C、D组小鼠肝、肾功能及血常规均无变化,未见有心、肺、脾、肾的病理改变及骨髓抑制等。注药后第3天起,D组肿瘤生长迅速,生长率在3、7、10、14d时分别为13%、20%、29%、36%,与A组(分别为-11%-、19%-、29%-、38%)、B组(分别为-6%、-9%-、11%-、16%)、C组(分别为-1%-、3%-、6%-、9%)比较,差异均有显著性,P均<0.01;各时间点A组生长率最低,与其他各组相比,差异有显著性,P均<0.05;B组也低于C组,差异有显著性,P均<0.05。D组在3~14d肿瘤坏死范围均未超过30%;A组肿瘤重度坏死率在3、7、10及14d时分别为58%、68%、77%及87%,与B、C、D组比较,差异有显著性,P均<0.01;B、C、D组坏死率呈降低趋势,且组间差异有显著性,P均<0.05。结论热碘油联合90Y瘤内注射治疗小鼠肝癌安全、有效。; Objective: To determine the safety and tolerability of hot lipiodol with ~(90)Y intratumor injection for treatment of mouse transplanted liver cancer.Methods: 40 Kunming mice transplanted liver cancer were randomly divided into 4 groups,and injected respectively with ~(90)Y in hot lipiodol(group A),hot lipiodol(group B),~(90)Y(group C),and physiological saline(groups D).Pathologic examination of the tumor and main organs,and the determination of liver and renal functions and routine blood test were performed. The Radiodistribution of ~(90)Y was measured.Results: In group A,the tumor growth was markedly retarded and eventually un-palpable.Histological examinations showed complete necrosis of the tumor.In groups B and up C,the tumor growth was also inhibited.However,Histological examinations showed incomplete necrosis of the tumors in groups B and C,while Only isolated,spotty foci of necrosis were present in the tumors of untreated control group(groups D).Conclusion: Intratumor injection of hot lipiodol with ~(90)Y is a safe,feasible and effective method to treat liver cancer. |
| 语种 | 中文 ; 中文 |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/35789]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | 牟培源,陈靖,孙锁柱,等. 热碘油联合~(90)Y瘤内注射治疗肝癌的实验研究[J],2010, 2010. |
| APA | 牟培源.,陈靖.,孙锁柱.,王建晨.,蒋小良.,...&SUN Suo-zhu.(2010).热碘油联合~(90)Y瘤内注射治疗肝癌的实验研究.. |
| MLA | 牟培源,et al."热碘油联合~(90)Y瘤内注射治疗肝癌的实验研究".(2010). |
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