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	Tumor thermal ablation therapy using alkali metals as powerful self-heating seeds
	Rao, Wei ; Liu, Jing
	2010-05-11 ; 2010-05-11
关键词	targeted tumor thermal ablation therapy minimally invasive treatment self-heating seeds alkali metal exothermic chemical reaction physical therapy INTENSITY FOCUSED ULTRASOUND HEPATOCELLULAR-CARCINOMA IN-VIVO CANCER COAGULATION Surgery
中文摘要	The aim of this study is to demonstrate a new tumor thermal ablation therapy, which might lead to a highly economic, safe and efficient heating of target tissues. The alkali metals, usually seen as hazard mediums in daily life, were proposed for the first time as perfect self-heating seeds which can significantly raise the temperature of the tumor tissues. Owing to the tremendous heat released at only the target site during reaction between the metal and the intrinsically existing wet environment of the biological body, the tumor tissues can be efficiently ablated without causing thermal damage to the surrounding healthy tissues. Several conceptual experiments were performed to demonstrate the new thermal ablation principle. Mammary adenocarcinoma cells in culture were found to be quickly destroyed due to the thermal and chemical effects induced by the alkali metal. Further, a significant temperature increase by a magnitude of > 40 degrees C or even combustion has been found easily available at the target site; this temperature increase produces a sufficiently large coagulation and necrosis area within selected areas either for in vitro or in vivo tests. The unique merit of the present thermal ablation therapy is that its remaining reactant can be absorbed by the tissue itself without causing any damage. This study opens possibilities of using the alkali metals to thermally ablate the target tumor in future clinical applications.
语种	英语 ; 英语
出版者	TAYLOR & FRANCIS AS ; OSLO ; PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27661]
专题	清华大学
推荐引用方式 GB/T 7714	Rao, Wei,Liu, Jing. Tumor thermal ablation therapy using alkali metals as powerful self-heating seeds[J],2010, 2010.
APA	Rao, Wei,&Liu, Jing.(2010).Tumor thermal ablation therapy using alkali metals as powerful self-heating seeds..
MLA	Rao, Wei,et al."Tumor thermal ablation therapy using alkali metals as powerful self-heating seeds".(2010).

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