| HIV type I phenotype, tropism, and sequence patterns: Association and preference | |
| Dong, XN ; Chen, X ; Chen, Y ; Ablimit, A ; Ye, Z ; Wu, Y ; Chen, YH | |
| 2010-05-11 ; 2010-05-11 | |
| 关键词 | IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 ENVELOPE GLYCOPROTEIN N-LINKED GLYCOSYLATION SYNCYTIUM-INDUCING PHENOTYPE CORECEPTOR USAGE TEMPORAL RELATIONSHIP DISEASE PROGRESSION V2 CONFIGURATION RECEPTOR MACROPHAGE Immunology Infectious Diseases Virology |
| 中文摘要 | In this study, the relationship between biological phenotypes, coreceptor usages, and sequence patterns of V1V2 or V3 regions on HIV-1 envelope gp 120 was carefully analyzed based on the existing isolates in the Los Alamos National Laboratory sequence database. Obviously, SI/NSI phenotypes were closely linked to the capability of HIV-1 to use coreceptor CXCR4, but not CCR5. Moreover, compared to NSI or R5 isolates, SI or X4 HIV-1 isolates significantly prefer higher net charges and the loss of the N-linked glycosylation site in the V3 loop, but they show no preference in either net charge or N-linked glycosylation of the V1V2 region. In addition, no significant relationship between V1V2 length and virus tropism or phenotypes was observed. |
| 语种 | 英语 ; 英语 |
| 出版者 | MARY ANN LIEBERT INC ; NEW ROCHELLE ; 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/26539]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Dong, XN,Chen, X,Chen, Y,et al. HIV type I phenotype, tropism, and sequence patterns: Association and preference[J],2010, 2010. |
| APA | Dong, XN.,Chen, X.,Chen, Y.,Ablimit, A.,Ye, Z.,...&Chen, YH.(2010).HIV type I phenotype, tropism, and sequence patterns: Association and preference.. |
| MLA | Dong, XN,et al."HIV type I phenotype, tropism, and sequence patterns: Association and preference".(2010). |
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