| Preparation and evaluation of porous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-hydroxyapatite composite scaffolds | |
| Xi, Jing ; Zhang, Ling ; Zheng, Zhenhuan ; Chen, Guoqiang ; Gong, Yandao ; Zhao, Nanming ; Zhang, Xiufang | |
| 2010-05-11 ; 2010-05-11 | |
| 关键词 | PHBHHx hydroxyapatite porous scaffold bone reconstruction IN-VITRO BIODEGRADABLE IMPLANT OSTEOBLAST ADHESION HYDROXYAPATITE CEMENT Engineering, Biomedical Materials Science, Biomaterials |
| 中文摘要 | Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and PHBHHx-hydroxyapatite (HAP) composite scaffolds have been prepared by phase separation and subsequent sublimation of the solvent for bone tissue engineering. Scanning electron microscopy (SEM), porosity measurement, mechanical tests, and thermogravimertric analysis (TGA) are used to analyze the physical properties of the scaffolds. The biocompatibility and osteoconductivity are assessed by examining the morphology, proliferation, and differentiation of MC3T3-E1 osteoprogenitor cells seeded on the scaffolds. The PHBHHx-HAP composite scaffolds show better mechanical properties, biocompatibility, and osteoconductivity than the PHBHHx scaffolds. The results suggest that PHBHHx-HAP composite scaffolds can be employed as a promising candidate for bone reconstruction. |
| 语种 | 英语 ; 英语 |
| 出版者 | SAGE PUBLICATIONS LTD ; LONDON ; 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/26470]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Xi, Jing,Zhang, Ling,Zheng, Zhenhuan,et al. Preparation and evaluation of porous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-hydroxyapatite composite scaffolds[J],2010, 2010. |
| APA | Xi, Jing.,Zhang, Ling.,Zheng, Zhenhuan.,Chen, Guoqiang.,Gong, Yandao.,...&Zhang, Xiufang.(2010).Preparation and evaluation of porous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-hydroxyapatite composite scaffolds.. |
| MLA | Xi, Jing,et al."Preparation and evaluation of porous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-hydroxyapatite composite scaffolds".(2010). |
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