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	Effect of surface roughness of chitosan-based microspheres on cell adhesion
	Qingfeng Zan ; Chen Wang ; Limin Dong ; Peng Cheng ; Jiemo Tian
	2010-05-10 ; 2010-05-10
关键词	Experimental/ adhesion biomedical materials bone cellular biophysics composite materials orthopaedics scanning electron microscopy surface roughness tissue engineering/ surface roughness chitosan-based microspheres cell adhesion microcarriers tissue-engineering scaffolds biomedical application smooth surface beta -TCP-chitosan composite microspheres coarse surface ceramic particles profilometer mouse MC3T3-E1 osteoblast ESEM MTT assay adherence osteoblast proliferation/ A8770M Biomedical materials A8725 Cellular biophysics
中文摘要	Microspheres are novel candidate materials for microcarriers and tissue-engineering scaffolds. Chitosan microspheres were selected as the base materials because of their excellent properties for biomedical applications. But their smooth surfaces were not adapted for cell attachment. Hence, in order to improve the roughness of chitosan microspheres, beta -TCP/chitosan composite microspheres were developed. From SEM photographs, the coarse surfaces of composite microspheres were observed, there were some ceramic particles standing out of the chitosan matrix. And their roughness measured by profilometers was about 2.0 mu m. Mouse MC3T3-E1 osteoblasts were seeded on the microspheres for evaluating the attachment interaction between cells and materials. According to the ESEM photographs and MTT assay, the adherence and proliferation of osteoblasts on the surfaces of modified microspheres were better than those on the chitosan microspheres, which were mainly attributed to the improved roughness of surface. [All rights reserved Elsevier].
语种	英语 ; 英语
出版者	Elsevier Science B.V. ; Netherlands
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/21593]
专题	清华大学
推荐引用方式 GB/T 7714	Qingfeng Zan,Chen Wang,Limin Dong,et al. Effect of surface roughness of chitosan-based microspheres on cell adhesion[J],2010, 2010.
APA	Qingfeng Zan,Chen Wang,Limin Dong,Peng Cheng,&Jiemo Tian.(2010).Effect of surface roughness of chitosan-based microspheres on cell adhesion..
MLA	Qingfeng Zan,et al."Effect of surface roughness of chitosan-based microspheres on cell adhesion".(2010).

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