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	Effect of surface roughness of chitosan-based microspheres on cell adhesion
	Zan, Qingfeng ; Wang, Chen ; Dong, Limin ; Cheng, Peng ; Tian, Jiemo
	2010-05-10 ; 2010-05-10 ; OCT 05-07, 2007
会议名称	APPLIED SURFACE SCIENCE ; 1st International Symposium on Surface and Interfaces of Biomaterials ; Chengdu, PEOPLES R CHINA ; Web of Science
关键词	Chitosan Microspheres Roughness beta-TCP Cell adhesion Chemistry, Physical Materials Science, Coatings & Films Physics, Applied Physics, Condensed Matter
中文摘要	Microspheres are novel candidate materials for microcarriers and tissue-engineering scaffolds. Chitosan microspheres were selected as the base materials because of their excellent properties for biomedical applications. But their smooth surfaces were not adapted for cell attachment. Hence, in order to improve the roughness of chitosan microspheres, beta-TCP/chitosan composite microspheres were developed. From SEM photographs, the coarse surfaces of composite microspheres were observed, there were some ceramic particles standing out of the chitosan matrix. And their roughness measured by profilometers was about 2.0 mm. Mouse MC3T3-E1 osteoblasts were seeded on the microspheres for evaluating the attachment interaction between cells and materials. According to the ESEM photographs and MTT assay, the adherence and proliferation of osteoblasts on the surfaces of modified microspheres were better than those on the chitosan microspheres, which were mainly attributed to the improved roughness of surface. (c) 2008 Elsevier B. V. All rights reserved.; SW Jiaotong Univ
会议录出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/18829]
专题	清华大学
推荐引用方式 GB/T 7714	Zan, Qingfeng,Wang, Chen,Dong, Limin,et al. Effect of surface roughness of chitosan-based microspheres on cell adhesion[C]. 见:APPLIED SURFACE SCIENCE, 1st International Symposium on Surface and Interfaces of Biomaterials, Chengdu, PEOPLES R CHINA, Web of Science.

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