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	Preparation of thermosensitive chitosan formulations containing 5-fluorouracil/poly-3-hydroxybutyrate microparticles used as injectable drug delivery system
	Zan, J ; Zhu, DQ ; Tan, FP ; Jiang, GQ ; Lin, Y ; Ding, FX
	2010-05-07 ; 2010-05-07
关键词	hydrogel chitosan injectables microparticle drug release RELEASE GELS 5-FLUOROURACIL COPOLYMERS HYDROGELS Engineering, Chemical
中文摘要	The auto-gelling and drug release properties of the thermosensitive chitosan-beta-glycerophosphate formulation were investigated. According to rheological study, gelation lag time of chitosan/beta-glycerophosphate (GP) solutions varied from 2 to 60 min with different deacetylation degree of chitosan, pH, gelation temperature, and the particles in the sol. The gelation properties were also found to influence the release profiles of a hydrophilic drug, 5-fluorouracil (5-FU). Morphological examination by scanning electron microphotography demonstrated that large "pores" occurred during the gel-forming process, which created hydrophilic environment and led to the rapid initial release of the drug (85% in first 8h). Poly-3-hydroxybutyrate (PHB), a biodegradable material, was applied here as scaffold to capture 5-FU into microparticles with high encapsulation efficiency by solvent-nonsolvent method. Combination of these microparticles into the chitosan-beta-GP formulation could drop the rapid initial release from 85% down to 29% in the optimized PHB content (75%, by mass). The release could sustain for about 10 months. This study provided an understanding of the potential of injectable implant using thermosensitive chitosan-beta-GP formulation containing PHB based particles for the water soluble drugs that need the property of long-term delivery.
语种	英语 ; 英语
出版者	CHEMICAL INDUSTRY PRESS ; BEIJING ; NO. 3 HUIXINLI CHAOYANGQU, BEIJING 100029, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/17248]
专题	清华大学
推荐引用方式 GB/T 7714	Zan, J,Zhu, DQ,Tan, FP,et al. Preparation of thermosensitive chitosan formulations containing 5-fluorouracil/poly-3-hydroxybutyrate microparticles used as injectable drug delivery system[J],2010, 2010.
APA	Zan, J,Zhu, DQ,Tan, FP,Jiang, GQ,Lin, Y,&Ding, FX.(2010).Preparation of thermosensitive chitosan formulations containing 5-fluorouracil/poly-3-hydroxybutyrate microparticles used as injectable drug delivery system..
MLA	Zan, J,et al."Preparation of thermosensitive chitosan formulations containing 5-fluorouracil/poly-3-hydroxybutyrate microparticles used as injectable drug delivery system".(2010).

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