| FeCl3-promoted intramolecular annulation of delta-keto nitriles: Facile approach to prepare 3-acetamido-2-pyridone derivatives | |
| Wang, SZ ; Pan, J ; Hu, YF ; Hu, HW | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | delta-keto nitrile 3-acetamido-2-pyridone ferric chloride HETEROBICYCLIC P-1-ARGININE MIMETICS FACTOR VIIA INHIBITORS STRUCTURE-BASED DESIGN 2-PYRIDONE-CONTAINING PEPTIDOMIMETICS BIOLOGICAL EVALUATION NOTHAPODYTINE-B THROMBIN 2-PYRIDONES OPTIMIZATION OXIDATION Chemistry, Organic |
| 中文摘要 | A facile approach was developed to synthesize 3-acetamido-2-pyridone derivatives in moderate yields from 6-keto nitrites, derived from Michael addition between ethyl acetamidocyanoacetate and alpha,beta-unsaturated ketones. The tandem reaction sequence promoted by FeCl3 involves intramolecular ketone-nitrite annulation followed by aromatization via selective decarbethoxylation. A plausible mechanism is also described. |
| 语种 | 英语 ; 英语 |
| 出版者 | GEORG THIEME VERLAG KG ; STUTTGART ; RUDIGERSTR 14, D-70469 STUTTGART, GERMANY |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/13403]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Wang, SZ,Pan, J,Hu, YF,et al. FeCl3-promoted intramolecular annulation of delta-keto nitriles: Facile approach to prepare 3-acetamido-2-pyridone derivatives[J],2010, 2010. |
| APA | Wang, SZ,Pan, J,Hu, YF,&Hu, HW.(2010).FeCl3-promoted intramolecular annulation of delta-keto nitriles: Facile approach to prepare 3-acetamido-2-pyridone derivatives.. |
| MLA | Wang, SZ,et al."FeCl3-promoted intramolecular annulation of delta-keto nitriles: Facile approach to prepare 3-acetamido-2-pyridone derivatives".(2010). |
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