Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway | |
Xu, Qingsong1; Wang, Wenjing2; Yang, Wen1; Du, Yuguang3; Song, Linsheng1 | |
刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES |
2017-05-01 | |
卷号 | 98页码:502-505 |
关键词 | Chitosan Oligosaccharide Epidermal Growth Factor Cell Growth |
ISSN号 | 0141-8130 |
DOI | 10.1016/j.ijbiornac.2017.02.021 |
文献子类 | Article |
英文摘要 | Chitosan oligosaccharide (COS) has been shown to regulate various cellular and biological functions. Epidermal growth factor (EGF) plays a significant role in tumorigenesis and invasiveness of some cancers. The aim of this study was to evaluate the effects of COS on EGF-induced cell growth and the further mechanisms. The results demonstrated that COS could inhibit EGF-induced epithelial GE11 cells proliferation in a dose dependent manner. In addition, EGF stimulated the epithelial cells to undergo morphological alteration, exhibiting mesenchymal cells higher metastatic and invasive potential, however, COS could partly suppress aforementioned morphological change. Signal transduction studies indicated COS repressed epidermal growth factor receptor (EGFR) phosphorylation and mitogen-activated protein kinase (MAPK) activation, but not Grb2, Ras, and Raf. Taken together, chitosan oligosaccharide inhibited EGF-induced cell growth and migration through blockade of the EGFR/MAPK signal transduction pathway. (C) 2017 Elsevier B.V. All rights reserved. |
WOS关键词 | To-mesenchymal Transition ; Tumor Microenvironment ; Breast-cancer ; Chitooligosaccharides ; Chitin ; Roles |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
语种 | 英语 |
WOS记录号 | WOS:000396950600056 |
资助机构 | National Natural Science Foundation of China(31372347 ; 31670807) |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/22153] |
专题 | 过程工程研究所_研究所(批量导入) |
作者单位 | 1.Dalian Ocean Univ, Coll Fisheries & Life Sci, 52 Heishijiao St, Dalian 116023, Peoples R China 2.Dalian Elite Analyt Instruments Co Ltd, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Qingsong,Wang, Wenjing,Yang, Wen,et al. Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,98:502-505. |
APA | Xu, Qingsong,Wang, Wenjing,Yang, Wen,Du, Yuguang,&Song, Linsheng.(2017).Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,98,502-505. |
MLA | Xu, Qingsong,et al."Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 98(2017):502-505. |
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