Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway
Xu, Qingsong1; Wang, Wenjing2; Yang, Wen1; Du, Yuguang3; Song, Linsheng1
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2017-05-01
卷号98页码:502-505
关键词Chitosan Oligosaccharide Epidermal Growth Factor Cell Growth
ISSN号0141-8130
DOI10.1016/j.ijbiornac.2017.02.021
文献子类Article
英文摘要

Chitosan oligosaccharide (COS) has been shown to regulate various cellular and biological functions. Epidermal growth factor (EGF) plays a significant role in tumorigenesis and invasiveness of some cancers. The aim of this study was to evaluate the effects of COS on EGF-induced cell growth and the further mechanisms. The results demonstrated that COS could inhibit EGF-induced epithelial GE11 cells proliferation in a dose dependent manner. In addition, EGF stimulated the epithelial cells to undergo morphological alteration, exhibiting mesenchymal cells higher metastatic and invasive potential, however, COS could partly suppress aforementioned morphological change. Signal transduction studies indicated COS repressed epidermal growth factor receptor (EGFR) phosphorylation and mitogen-activated protein kinase (MAPK) activation, but not Grb2, Ras, and Raf. Taken together, chitosan oligosaccharide inhibited EGF-induced cell growth and migration through blockade of the EGFR/MAPK signal transduction pathway. (C) 2017 Elsevier B.V. All rights reserved.

WOS关键词To-mesenchymal Transition ; Tumor Microenvironment ; Breast-cancer ; Chitooligosaccharides ; Chitin ; Roles
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000396950600056
资助机构National Natural Science Foundation of China(31372347 ; 31670807)
内容类型期刊论文
源URL[http://ir.ipe.ac.cn/handle/122111/22153]  
专题过程工程研究所_研究所(批量导入)
作者单位1.Dalian Ocean Univ, Coll Fisheries & Life Sci, 52 Heishijiao St, Dalian 116023, Peoples R China
2.Dalian Elite Analyt Instruments Co Ltd, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Xu, Qingsong,Wang, Wenjing,Yang, Wen,et al. Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,98:502-505.
APA Xu, Qingsong,Wang, Wenjing,Yang, Wen,Du, Yuguang,&Song, Linsheng.(2017).Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,98,502-505.
MLA Xu, Qingsong,et al."Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 98(2017):502-505.
个性服务
查看访问统计
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。


©版权所有 ©2017 CSpace - Powered by CSpace