Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy
	Zhang, Chen 1; Ni, Dalong 1; Liu, Yanyan 1; Yao, Heliang 1; Bu, Wenbo 1,2; Shi, Jianlin 1
刊名	NATURE NANOTECHNOLOGY
	2017-04-01
卷号	12 期号:4 页码:378-386
英文摘要	A material that rapidly absorbs molecular oxygen (known as an oxygen scavenger or deoxygenation agent (DOA)) has various industrial applications, such as in food preservation, anticorrosion of metal and coal deoxidation. Given that oxygen is vital to cancer growth, to starve tumours through the consumption of intratumoral oxygen is a potentially useful strategy in fighting cancer. Here we show that an injectable polymer-modified magnesium silicide (Mg2Si) nanoparticle can act as a DOA by scavenging oxygen in tumours and form by-products that block tumour capillaries from being reoxygenated. The nanoparticles are prepared by a self-propagating high-temperature synthesis strategy. In the acidic tumour microenvironment, the Mg2Si releases silane, which efficiently reacts with both tissue-dissolved and haemoglobin-bound oxygen to form silicon oxide (SiO2) aggregates. This in situ formation of SiO2 blocks the tumour blood capillaries and prevents tumours from receiving new supplies of oxygen and nutrients.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
关键词[WOS]	STIMULI-RESPONSIVE NANOCARRIERS ; INDUCED CELL-DEATH ; GOLD NANOPARTICLES ; SOLID TUMORS ; OXYGEN ; HYPOXIA ; ANGIOGENESIS ; COMBUSTION ; COMPOUND ; DELIVERY
收录类别	SCI
语种	英语
WOS记录号	WOS:000398767500019
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23787]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Chen,Ni, Dalong,Liu, Yanyan,et al. Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy[J]. NATURE NANOTECHNOLOGY,2017,12(4):378-386.
APA	Zhang, Chen,Ni, Dalong,Liu, Yanyan,Yao, Heliang,Bu, Wenbo,&Shi, Jianlin.(2017).Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.NATURE NANOTECHNOLOGY,12(4),378-386.
MLA	Zhang, Chen,et al."Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy".NATURE NANOTECHNOLOGY 12.4(2017):378-386.