Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy

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	Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy
	Dong, Qianqian 1,2; Li, Jieling 2; Cui, Lingyun 2; Jian, Honglei 2; Wang, Anhe 2; Bai, Shuo 2
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2017-03-05
卷号	516 页码:190-198
关键词	CaCO3 nanoparticles Hyaluronic acid Photosensitizer Photodynamic therapy
ISSN号	0927-7757
英文摘要	The solubility and stability of hydrophobic photosensitizer in aqueous solution have a great effect on the efficiency of Photodynamic Therapy (PDT) in cancer treatment. Herein, porous CaCO3 nanoparticles with a size about 250 nm were prepared as a carrier for the photosensitizer Hypocrellin B (HB) to improve the encapsulation and delivery in aqueous solution. The encapsulation dosage of HB by porous CaCO3 nanoparticles was investigated and proved to be concentration dependent. After modified by cross-linked targeting molecule hyaluronic acid (HA), the hybrid nanoparticles were demonstrated the advantages for HB release by pH sensitive structure and enhancement of PDT cytotoxicity to cancer cells. The hybrid nanoparticles obtained here are supposed to have a great potential application in the PDT. (C) 2016 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Physical
研究领域[WOS]	Chemistry
关键词[WOS]	SILICA NANOPARTICLES ; SOLVENT EXCHANGE ; GOLD NANOCAGES ; DRUG-RELEASE ; CANCER-CELLS ; PARTICLES ; DELIVERY ; BIOMINERALIZATION ; CAPSULES ; BEADS
收录类别	SCI
语种	英语
WOS记录号	WOS:000393727700021
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/21962]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Harbin Univ Sci & Technol, Coll Chem & Environm Engn, Harbin 150040, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Dong, Qianqian,Li, Jieling,Cui, Lingyun,et al. Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2017,516:190-198.
APA	Dong, Qianqian,Li, Jieling,Cui, Lingyun,Jian, Honglei,Wang, Anhe,&Bai, Shuo.(2017).Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,516,190-198.
MLA	Dong, Qianqian,et al."Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 516(2017):190-198.