Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy

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	Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy
	Liu, Yamei 1,2; Ma, Kai 1,2; Jiao, Tifeng 1,2; Xing, Ruirui 1,2; Shen, Guizhi 3; Yan, Xuehai 3
刊名	SCIENTIFIC REPORTS
	2017-02-23
卷号	7
ISSN号	2045-2322
英文摘要	Nanoengineering of hydrophobic photosensitizers (PSs) is a promising approach for improved tumor delivery and enhanced photodynamic therapy (PDT) efficiency. A variety of delivery carriers have been developed for tumor delivery of PSs through the enhanced permeation and retention (EPR) effect. However, a high-performance PS delivery system with minimum use of carrier materials with excellent biocompatibility is highly appreciated. In this work, we utilized the spatiotemporal interfacial adhesion and assembly of supramolecular coordination to achieve the nanoengineering of water-insoluble photosensitizer Chlorin e6 (Ce6). The hydrophobic Ce6 nanoparticles are well stabilized in a aqueous medium by the interfacially-assembled film due to the coordination polymerization of tannic acid (TA) and ferric iron (Fe(III)). The resulting Ce6@ TA-Fe(III) complex nanoparticles (referenced as Ce6@ TA-Fe(III) NPs) significantly improves the drug loading content (similar to 65%) and have an average size of 60 nm. The Ce6@TA-Fe(III) NPs are almost non-emissive as the aggregated states, but they can light up after intracellular internalization, which thus realizes low dark toxicity and excellent phototoxicity under laser irradiation. The Ce6@TA-Fe(III) NPs prolong blood circulation, promote tumor-selective accumulation of PSs, and enhanced antitumor efficacy in comparison to the free-carrier Ce6 in vivo evaluation.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	DRUG-DELIVERY ; NANOPARTICLES ; PROTEIN ; MECHANISMS ; CANCER ; LOCALIZATION ; DESTRUCTION ; LIPOSOMES ; NANODRUGS ; VEHICLES
收录类别	SCI
语种	英语
WOS记录号	WOS:000394766100001
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/21957]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China 2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yamei,Ma, Kai,Jiao, Tifeng,et al. Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy[J]. SCIENTIFIC REPORTS,2017,7.
APA	Liu, Yamei,Ma, Kai,Jiao, Tifeng,Xing, Ruirui,Shen, Guizhi,&Yan, Xuehai.(2017).Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy.SCIENTIFIC REPORTS,7.
MLA	Liu, Yamei,et al."Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy".SCIENTIFIC REPORTS 7(2017).