From Palladium to Bronsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones | |
Zhou H(周慧)1,2; Wei, Zhao1,2; Zhang JL(张金龙)1; Yang HM(杨化萌)1; Xia CG(夏春谷)1; Jiang GX(蒋高喜)1 | |
刊名 | Angewandte Chemie International Edition |
2017 | |
卷号 | 56期号:4页码:1077-1081 |
关键词 | allenes allylic compounds Bronsted acids heterocycles palladium |
ISSN号 | 1433-7851 |
通讯作者 | 蒋高喜 |
英文摘要 | A highly enantioselective regiodivergent addition of alkoxyallenes to pyrazolones was developed to afford multiply functionalized alkylated products bearing a quaternary carbon stereocenter in high yields with excellent stereoselectivities. One approach is enabled by palladium catalysis, thus leading to branched allylic pyrazol-5-ones under mild reaction conditions. The other is catalyzed by a chiral Brønsted acid to give linear products exclusively. Moreover, the usefulness of this new method was highlighted by converting the allylic products into other interesting multifunctionalized pyrazolone derivatives which would be of great potential for the exploitation of pharmaceutically important molecules. |
学科主题 | 物理化学与绿色催化 |
收录类别 | SCI |
资助信息 | Hundred Talent Program of Chinese Academy of Sciences (CAS);the National Natural Science Foundation of China (21202175;21602231);the Natural Science Foundation of Jiangsu (BK20160396) |
语种 | 英语 |
WOS记录号 | WOS:000394997200026 |
内容类型 | 期刊论文 |
源URL | [http://210.77.64.217/handle/362003/21478] |
专题 | 兰州化学物理研究所_苏州研究院 兰州化学物理研究所_OSSO国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, LICP, Suzhou Res Inst LICP, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou H,Wei, Zhao,Zhang JL,et al. From Palladium to Bronsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones[J]. Angewandte Chemie International Edition,2017,56(4):1077-1081. |
APA | Zhou H,Wei, Zhao,Zhang JL,Yang HM,Xia CG,&Jiang GX.(2017).From Palladium to Bronsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones.Angewandte Chemie International Edition,56(4),1077-1081. |
MLA | Zhou H,et al."From Palladium to Bronsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones".Angewandte Chemie International Edition 56.4(2017):1077-1081. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论