Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody

CORC > 天津工业生物技术研究所 > 蛋白质工程与疫苗实验室高福 > 期刊论文

	Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody
	Dai, Lianpan 1; Song, Jian 2,3; Lu, Xishan 4; Deng, Yong-Qiang 5; Musyoki, Abednego Moki 2,3; Cheng, Huijun 1; Zhang, Yanfang 4; Yuan, Yuan 2,3; Song, Hao 2,3; Haywood, Joel 2,3
刊名	CELL HOST & MICROBE
	2016-05-11
卷号	19 期号:5 页码:696-704
英文摘要	Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major target of neutralizing antibodies for other flaviviruses. Here, we report the structures of ZIKV E protein at 2.0 angstrom and in complex with a flavivirus broadly neutralizing murine antibody 2A10G6 at 3.0 angstrom. ZIKV-E resembles all the known flavivirus E structures but contains a unique, positively charged patch adjacent to the fusion loop region of the juxtaposed monomer, which may influence host attachment. The ZIKV-E-2A10G6 complex structure reveals antibody recognition of a highly conserved fusion loop. 2A10G6 binds to ZIKV-E with high affinity in vitro and neutralizes currently circulating ZIKV strains in vitro and in mice. The E protein fusion loop epitope represents a potential candidate for therapeutic antibodies against ZIKV.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Microbiology ; Parasitology ; Virology
研究领域[WOS]	Microbiology ; Parasitology ; Virology
关键词[WOS]	WEST-NILE-VIRUS ; CROSS-REACTIVE ANTIBODIES ; HUMAN MONOCLONAL-ANTIBODIES ; DENGUE VIRUS ; FUSION-LOOP ; NEUTRALIZING ANTIBODIES ; EBOLA-VIRUS ; ENCEPHALITIS-VIRUS ; CRYSTAL-STRUCTURE ; ASIAN LINEAGE
收录类别	SCI
语种	英语
WOS记录号	WOS:000375595500019
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/2259]
专题	天津工业生物技术研究所_蛋白质工程与疫苗实验室高福_期刊论文
作者单位	1.Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth RNIH, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100071, Peoples R China 3.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China 5.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100101, Peoples R China 6.Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen 518112, Peoples R China 7.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China 8.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Engn, Beijing 100101, Peoples R China 9.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China 10.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China
推荐引用方式 GB/T 7714	Dai, Lianpan,Song, Jian,Lu, Xishan,et al. Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody[J]. CELL HOST & MICROBE,2016,19(5):696-704.
APA	Dai, Lianpan.,Song, Jian.,Lu, Xishan.,Deng, Yong-Qiang.,Musyoki, Abednego Moki.,...&Gao, George F..(2016).Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody.CELL HOST & MICROBE,19(5),696-704.
MLA	Dai, Lianpan,et al."Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody".CELL HOST & MICROBE 19.5(2016):696-704.