Lysosomes activating chain reactions against cancer cells with a pH- switched prodrug/procatalyst co-delivery nanosystem

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 特种无机涂层重点实验室 > 期刊论文

	Lysosomes activating chain reactions against cancer cells with a pH- switched prodrug/procatalyst co-delivery nanosystem
	Fu, Jingke 1,2; Zhu, Yingchun 1
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2017
卷号	5 期号:5 页码:996-1004
英文摘要	Conventional chemotherapy uses potent toxic drugs to destroy cancer cells and always causes severe systemic toxicity in patients. In this respect, a smart and pH-switched prodrug/procatalyst co-delivery nanosystem is developed which is non-toxic toward normal cells and is inert during its delivery in the vasculature, while responsively functions in acidic lysosomes inside cancer cells. Synthetically, non-toxic artemisinin (ART) was used as the prodrug and loaded into the inner space of hollow mesoporous silica (HMS) nanoparticles (NPs). Subsequently, Fe3O4 NPs were efficiently capped onto pore outlets of HMS via acid labile acetal linkers (ART@ HMS-Fe3O4). ART@ HMS-Fe3O4 was stable under neutral conditions (pH 7.4) with almost no leakage of ART. Upon exposure to the acidic lysosomal compartment (pH 3.8-5.0) in cells, the acetal linkers were hydrolyzed which led to sustained release of both ART and Fe3O4 NPs. Under the activation of the lysosomal environment, the liberated Fe3O4 NPs were metabolized to free iron ions and catalyzed the generation of high amounts of free radicals from the released ART in cells. In vitro cytotoxicity assay revealed excellent anticancer efficacy of this ART/Fe3O4 co-delivery nanosystem. The Fe3O4 NPs acted both as gatekeepers and procatalysts which inhibited ART from leakage during their delivery, while released ART and activated chain reactions to form free radicals in acidic lysosomes inside cancer cells. We visualize that this lysosomal environment-responsive ART@ HMS-Fe3O4 nanosystem could serve as an efficient and desirable chemotherapeutic nanosystem for cancer therapy.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Materials Science, Biomaterials
研究领域[WOS]	Materials Science
关键词[WOS]	MESOPOROUS SILICA NANOPARTICLES ; FREE-RADICAL GENERATION ; ANTIMALARIAL-DRUGS ; CONTROLLED-RELEASE ; TARGETED DELIVERY ; IRON ; MECHANISM ; ARTEMISININ ; TUMOR ; BIOADSORPTION
收录类别	SCI
语种	英语
WOS记录号	WOS:000395908000012
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23593]
专题	上海硅酸盐研究所_特种无机涂层重点实验室_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Fu, Jingke,Zhu, Yingchun. Lysosomes activating chain reactions against cancer cells with a pH- switched prodrug/procatalyst co-delivery nanosystem[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(5):996-1004.
APA	Fu, Jingke,&Zhu, Yingchun.(2017).Lysosomes activating chain reactions against cancer cells with a pH- switched prodrug/procatalyst co-delivery nanosystem.JOURNAL OF MATERIALS CHEMISTRY B,5(5),996-1004.
MLA	Fu, Jingke,et al."Lysosomes activating chain reactions against cancer cells with a pH- switched prodrug/procatalyst co-delivery nanosystem".JOURNAL OF MATERIALS CHEMISTRY B 5.5(2017):996-1004.