Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality
	Huang, Ping 1; Chen, Yu 2; Lin, Han 2; Yu, Luodan 2; Zhang, Linlin 2; Wang, Liying 2; Zhu, Yufang 1; Shi, Jianlin 2
刊名	BIOMATERIALS
	2017-05-01
卷号	125 页码:23-37
关键词	Mesoporous organosilica Hollow Cancer therapy Biodegradability Drug delivery
英文摘要	Based on the intrinsic features of high stability and unique multifunctionality, inorganic nanoparticles have shown remarkable potentials in combating cancer, but their biodegradability and biocompatibility are still under debate. As a paradigm, this work successfully demonstrates that framework organic inorganic hybridization can endow the inorganic mesoporous silica nanocarriers with unique tumor sensitive biodegradability and high biocompatibility. Based on a "chemical homology" mechanism, molecularly organic-inorganic hybridized hollow mesoporous organosilica nanocapsules (HMONs) with high dispersity and sub-50 nm particle dimension were constructed in mass production. A physiologically active disulfide bond (-S-S-) was directly incorporated into the silica framework, which could break up upon contacting the reducing microenvironment of tumor tissue and biodegrade accordingly. Such a tumor-specific biodegradability is also responsible for the tumor-responsive drug releasing by the fast biodegradation and disintegration of the framework. The ultrasmall particle size of HMONs guarantees their high accumulation into tumor tissue, thus causing the high chemotherapeutic outcome. This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance. (C) 2017 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	SILICA NANOCOMPOSITE NANOPARTICLES ; CONTROLLED DRUG-DELIVERY ; PROTEIN CORONA ; CONTROLLED-RELEASE ; CANCER-THERAPY ; BIOMEDICAL APPLICATIONS ; PHOTODYNAMIC THERAPY ; MAGNETIC-RESONANCE ; POLYMERIC MICELLES ; ORGANIC GROUPS
收录类别	SCI
语种	英语
WOS记录号	WOS:000396970500004
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23706]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, Shanghai 200093, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Huang, Ping,Chen, Yu,Lin, Han,et al. Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality[J]. BIOMATERIALS,2017,125:23-37.
APA	Huang, Ping.,Chen, Yu.,Lin, Han.,Yu, Luodan.,Zhang, Linlin.,...&Shi, Jianlin.(2017).Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.BIOMATERIALS,125,23-37.
MLA	Huang, Ping,et al."Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality".BIOMATERIALS 125(2017):23-37.