Phase-Transition Nanodroplets for Real-Time Photoacoustic/Ultrasound Dual-Modality Imaging and Photothermal Therapy of Sentinel Lymph Node in Breast Cancer

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Phase-Transition Nanodroplets for Real-Time Photoacoustic/Ultrasound Dual-Modality Imaging and Photothermal Therapy of Sentinel Lymph Node in Breast Cancer
	Yang, Lu 1,2,3; Cheng, Juan 1,2; Chen, Yuli 1,2; Yu, Shengjie 4; Liu, Fengqiu 1,2; Sun, Yang 1,2; Chen, Yu 5; Ran, Haitao 1,2
刊名	SCIENTIFIC REPORTS
	2017-03-24
卷号	7
英文摘要	Pathological status of lymph nodes (LNs) plays a critical role in staging and treatment for the patients with breast cancer. Sentinel lymph node biopsy has become the standard method in determining pathological status of axillary LNs. Therefore, the determination of sentinel lymph nodes (SLNs) and therapy of metastatic LNs are highly desirable in clinic. Herein, an unprecedented carbon nanoparticles (CNs)-incorporated liquid-gas phase-transition nanodroplets (CNPs) with strong near-infrared (NIR) absorption, good biocompatibility, excellent photoacoustic (PA) and ultrasound (US) contrast, and high photothermal-conversion efficiency are reported in this study. Upon laser irradiation, liquid-gas phase transition of the CNPs has been demonstrated to provide excellent contrasts for PA/US dual-modality imaging both in vitro and in vivo. Additionally, the CNPs are capable of staining lymph nodes, which can contribute significantly to the identification of LNs with naked eyes. With increased laser energy, the CNPs exhibit the high performance in killing the breast cancer cells both in vitro and in vivo, due to the photothermal effect induced from the CNs within CNPs. These results suggest that the developed multifunctional phase-transition nanodroplets have high potential to act as the theranostic agents in both SLNs detection and therapy of metastatic LNs.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	SUPERPARAMAGNETIC IRON-OXIDE ; CONTRAST-ENHANCED ULTRASOUND ; WALLED CARBON NANOTUBES ; AXILLARY ULTRASOUND ; BIOPSY ; NANOPARTICLES ; MICROBUBBLES ; LOCALIZATION ; DRUG ; VALIDATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000397292500001
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23699]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China 2.Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China 3.Chongqing Med Univ, Affiliated Hosp 2, Dept Breast Thyriod Pancreas Surg, Chongqing 400010, Peoples R China 4.Chongqing Med Univ, Affiliated Hosp 2, Dept Urinary Surg, Chongqing 400010, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Yang, Lu,Cheng, Juan,Chen, Yuli,et al. Phase-Transition Nanodroplets for Real-Time Photoacoustic/Ultrasound Dual-Modality Imaging and Photothermal Therapy of Sentinel Lymph Node in Breast Cancer[J]. SCIENTIFIC REPORTS,2017,7.
APA	Yang, Lu.,Cheng, Juan.,Chen, Yuli.,Yu, Shengjie.,Liu, Fengqiu.,...&Ran, Haitao.(2017).Phase-Transition Nanodroplets for Real-Time Photoacoustic/Ultrasound Dual-Modality Imaging and Photothermal Therapy of Sentinel Lymph Node in Breast Cancer.SCIENTIFIC REPORTS,7.
MLA	Yang, Lu,et al."Phase-Transition Nanodroplets for Real-Time Photoacoustic/Ultrasound Dual-Modality Imaging and Photothermal Therapy of Sentinel Lymph Node in Breast Cancer".SCIENTIFIC REPORTS 7(2017).